New steroids from Anemarrhena asphodeloides rhizome and their -glucosidase inhibitory activity

被引：6
作者：
Pham Van Khang [1 ,2 ]
Dao Mai Phuong [1 ]
Ma, Lei [2 ]
机构：
[1] Thai Nguyen Univ Educ, Fac Chem, Thai Nguyen City 250000, Vietnam
[2] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2017年 / 19卷 / 05期
关键词：
Anemarrhena asphodeloides; steroid; -glucosidase; inhibitory activity; SARSASAPOGENIN; CELLS; GLYCOSIDES; APOPTOSIS;
D O I：
10.1080/10286020.2016.1234459
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new steroids were isolated from acid hydrolysis residue of the rhizomes of Anemarrhena asphodeloides. Their structures were identified on the basis of several spectroscopic analysis approaches including 1D, 2D-NMR techniques, and MS data, and by the comparison of spectral data of the known compounds. The biological activities of these two isolated compounds were explored on -glucosidase. Compound 1 displayed 4.7 folds inhibitory activity against -glucosidase compared with the positive control acarbose.
引用
收藏
页码：468 / 473
页数：6
相关论文
共 22 条
  • [1] [Anonymous], CHEM PHARM B
  • [2] The apoptotic effect of sarsasapogenin from Anemarrhena asphodeloides on HepG2 human hepatoma cells
    Bao, Wenna
    Pan, Haifeng
    Lu, Min
    Ni, Yuan
    Zhang, Rui
    Gong, Xingguo
    [J]. CELL BIOLOGY INTERNATIONAL, 2007, 31 (09) : 887 - 892
  • [3] NMR STUDIES AND ABSOLUTE CONFIGURATION OF SOLANUM ALKALOIDS (SPIROAMINOKETAL ALKALOIDS)
    BOLL, PM
    VONPHILI.W
    [J]. ACTA CHEMICA SCANDINAVICA, 1965, 19 (06): : 1365 - &
  • [4] DONG J X, 1992, Yaoxue Xuebao, V27, P26
  • [5] A new approach to the pharmacological regulation of memory: Sarsasapogenin improves memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models
    Hu, Y
    Xia, ZQ
    Sun, QX
    Orsi, A
    Rees, D
    [J]. BRAIN RESEARCH, 2005, 1060 (1-2) : 26 - 39
  • [6] Steroids from the roots of Asparagus officinalis and their cytotoxic activity
    Huang, Xue-Feng
    Lin, Yu-Ying
    Kong, Ling-Yi
    [J]. JOURNAL OF INTEGRATIVE PLANT BIOLOGY, 2008, 50 (06) : 717 - 722
  • [7] Inhibitory effects of compounds from Anemarrhenae Rhizoma on α-glucosidase and aldose reductase and its contents by drying conditions
    Ichiki, Hiroyuki
    Takeda, Osami
    Sakakibara, Iwao
    Terabayashi, Susumu
    Takeda, Shuichi
    Sasaki, Hiroshi
    [J]. JOURNAL OF NATURAL MEDICINES, 2007, 61 (02) : 146 - 153
  • [8] Effect of timosaponin E1 and E2 on superoxide generation induced by various stimuli in human neutrophils and on platelet aggregation in human blood
    Kaname, N
    Zhang, JY
    Meng, ZY
    Xu, SX
    Sugahara, K
    Doi, Y
    Kodama, H
    [J]. CLINICA CHIMICA ACTA, 2000, 295 (1-2) : 129 - 140
  • [9] Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of Anemarrhena asphodeloides in LPS-induced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-κB and p38 pathways
    Kim, Ji-Yeon
    Shin, Ji-Sun
    Ryu, Jong Hoon
    Kim, Sun Yeou
    Cho, Young-Wuk
    Choi, Jung-Hye
    Lee, Kyung-Tae
    [J]. FOOD AND CHEMICAL TOXICOLOGY, 2009, 47 (07) : 1610 - 1617
  • [10] Steroidal saponins from Anemarrhena asphodeloides
    Liu, Qing-Bo
    Peng, Ying
    Li, Ling-Zhi
    Gao, Pin-Yi
    Sun, Yu
    Yu, Li-Hong
    Song, Shao-Jiang
    [J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2013, 15 (08) : 891 - 898
123