Mass-spectrometry analysis of the human pineal proteome during night and day and in autism

被引：3

作者：

Dumas, Guillaume ^{[1
,2
]}

Goubran-Botros, Hany ^{[1
]}

Matondo, Mariette ^{[3
]}

Pagan, Cecile ^{[4
,5
]}

Boulegue, Cyril ^{[3
]}

Chaze, Thibault ^{[3
]}

Chamot-Rooke, Julia ^{[3
]}

Maronde, Erik ^{[6
]}

Bourgeron, Thomas ^{[1
]}

机构：

[1] Univ Paris Diderot, Human Genet & Cognit Funct, Inst Pasteur, UMR CNRS 3571, Paris, France

[2] Univ Montreal, Dept Psychiat, CHU Ste Justine Res Ctr, Precis Psychiat & Social Physiol Lab, Quebec City, PQ, Canada

[3] Ctr Ressources & Rech Technol C2RT, Inst Pasteur, Unite Spect Masse Biol MSBio, USR CNRS 2000, Paris, France

[4] Paris Descartes Univ, Paris, France

[5] Hop Lariboisiere, APHP, INSERM U942, Serv Biochim & Biol Mol, Paris, France

[6] Goethe Univ, Fac Med, Inst Anat 2, Frankfurt, Germany

来源：

JOURNAL OF PINEAL RESEARCH | 2021年 / 70卷 / 03期

关键词：

antioxidant; autism spectrum disorders; chaperon proteins; circadian rhythm; energy production; mass spectrometry; pineal gland; HYDROXYINDOLE-O-METHYLTRANSFERASE; MELATONIN SYNTHESIS; N-ACETYLTRANSFERASE; NOREPINEPHRINE STIMULATION; CIRCUMVENTRICULAR ORGANS; DIFFERENTIAL EXPRESSION; CREB PHOSPHORYLATION; ALZHEIMERS-DISEASE; CIRCADIAN-RHYTHMS; CRYSTAL-STRUCTURE;

D O I：

10.1111/jpi.12713

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The human pineal gland regulates day-night dynamics of multiple physiological processes, especially through the secretion of melatonin. Using mass-spectrometry-based proteomics and dedicated analysis tools, we identify proteins in the human pineal gland and analyze systematically their variation throughout the day and compare these changes in the pineal proteome between control specimens and donors diagnosed with autism. Results reveal diverse regulated clusters of proteins with, among others, catabolic carbohydrate process and cytoplasmic membrane-bounded vesicle-related proteins differing between day and night and/or control versus autism pineal glands. These data show novel and unexpected processes happening in the human pineal gland during the day/night rhythm as well as specific differences between autism donor pineal glands and those from controls.

引用

页数：17

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