Bioproduction of riboflavin: a bright yellow history

被引：87

作者：

Luis Revuelta, Jose ^{[1
]}

Ledesma-Amaro, Rodrigo ^{[1
]}

Lozano-Martinez, Patricia ^{[1
]}

Diaz-Fernandez, David ^{[1
]}

Buey, Ruben M. ^{[1
]}

Jimenez, Alberto ^{[1
]}

机构：

[1] Univ Salamanca, Dept Microbiol & Genet, Metab Engn Grp, Edificio Dept,Lab 323, Salamanca 38007, Spain

来源：

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY | 2017年 / 44卷 / 4-5期

关键词：

Vitamin B-2; Riboflavin fermentation; Bacillus subtilis; Ashbya gossypii; ASHBYA-GOSSYPII; BACILLUS-SUBTILIS; PURINE PATHWAY; SACCHAROMYCES-CEREVISIAE; MOLECULAR CHARACTERIZATION; ISOCITRATE LYASE; GENOME; GENE; FLUX; OVEREXPRESSION;

D O I：

10.1007/s10295-016-1842-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Riboflavin (vitamin B-2) is an essential nutrient for humans and animals that must be obtained from the diet. To ensure an optimal supply, riboflavin is used on a large scale as additive in the food and feed industries. Here, we describe a historical overview of the industrial process of riboflavin production starting from its discovery and the need to produce the vitamin in bulk at prices that would allow for their use in human and animal nutrition. Riboflavin was produced industrially by chemical synthesis for many decades. At present, the development of economical and eco-efficient fermentation processes, which are mainly based on Bacillus subtilis and Ashbya gossypii strains, has replaced the synthetic process at industrial scale. A detailed account is given of the development of the riboflavin overproducer strains as well as future prospects for its improvement.

引用

页码：659 / 665

页数：7

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