Copper supported β-cyclodextrin grafted magnetic nanoparticles as an efficient recyclable catalyst for one-pot synthesis of 1-benzyl-1H-1,2,3-triazoldibenzodiazepinone derivatives via click reaction

An efficient and recoverable copper catalyst was prepared by the immobilization of Cu into beta-cyclodextrin covalently attached to magnetic nanoparticles (denoted as [Cu@beta-CD@SPIONs]). A novel and one-pot synthetic approach was introduced for the synthesis of novel 1-benzyl-1H-1,2,3-triazoldibenzodiazepinone derivatives through a click reaction using [Cu@beta-CD@SPIONs] as a green catalyst. The magnetic recoverable catalyst was characterized using TEM, VSM, TGA, and FT-IR techniques. This nanocatalyst appeared efficient and robust in a multicomponent reaction for the preparation of benzodiazepinones followed by a click reaction for the synthesis of 1,2,3-triazoles in an ethanol/water mixture as solvent at room temperature under mild reaction conditions and with a facile work-up process. Interesting features including water-tolerance, robustness, efficiency, mild reaction conditions, utilization of green solvents, and simple catalyst recovery make [Cu@beta-CD@SPIONs] favourable from economic and environmental points of view.