Complement system and age-related macular degeneration: drugs and challenges

被引：61
作者：
Wu, Jiali [1 ]
Sun, Xiaodong [1 ,2 ,3 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Ophthalmol, Sch Med, 100 Haining Rd, Shanghai 200080, Peoples R China
[2] Shanghai Key Lab Fundus Dis, Shanghai, Peoples R China
[3] Shanghai Engn Ctr Visual Sci & Photomed, Shanghai, Peoples R China
来源：
DRUG DESIGN DEVELOPMENT AND THERAPY | 2019年 / 13卷
基金：
中国国家自然科学基金;
关键词：
age-related macular degeneration; inflammation; complement system; immunotherapy; RARE GENETIC-VARIANTS; GEOGRAPHIC ATROPHY; DRUSEN FORMATION; INHIBITION; ACTIVATION; PATHWAY; COMPSTATIN; DEPOSITS; THERAPIES; FRAGMENT;
D O I：
10.2147/DDDT.S206355
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Age-related macular degeneration (AMD) is directly attributable to vision loss, posing significant pressure on public health. AMD is recognized to be a multi-factorial disease and among them, complement system is under heated discussion in recent years. In this review, we start with an overview of complement pathways involved in AMD and their therapies correspondingly. Finally, we discuss the development of the therapeutics existed now. Also, we enclose a list of drugs undergoing clinical trials.
引用
收藏
页码：2413 / 2425
页数：13
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