From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery

被引：838

作者：

Banks, William A. ^{[1
,2
]}

机构：

[1] Vet Affairs Puget Sound Hlth Care Syst, Geriatr Res Educ & Clin Ctr, 1660 S Columbian Way, Seattle, WA 98108 USA

[2] Univ Washington, Sch Med, Dept Med, Div Gerontol & Geriatr Med, 1660 S Columbian Way, Seattle, WA 98108 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2016年 / 15卷 / 04期

关键词：

AMYLOID-BETA-PROTEIN; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; RECEPTOR-RELATED PROTEIN-1; MOUSE CEREBRAL PERICYTES; NECROSIS-FACTOR-ALPHA; SPINAL-CORD BARRIER; CEREBROSPINAL-FLUID; ALZHEIMERS-DISEASE; ENDOTHELIAL-CELLS; P-GLYCOPROTEIN;

D O I：

10.1038/nrd.2015.21

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

One of the biggest challenges in the development of therapeutics for central nervous system (CNS) disorders is achieving sufficient blood-brain barrier (BBB) penetration. Research in the past few decades has revealed that the BBB is not only a substantial barrier for drug delivery to the CNS but also a complex, dynamic interface that adapts to the needs of the CNS, responds to physiological changes, and is affected by and can even promote disease. This complexity confounds simple strategies for drug delivery to the CNS, but provides a wealth of opportunities and approaches for drug development. Here, I review some of the most important areas that have recently redefined the BBB and discuss how they can be applied to the development of CNS therapeutics.

引用

页码：275 / +

页数：18

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