From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery

被引：795

作者：

Banks, William A. ^{[1
,2
]}

机构：

[1] Vet Affairs Puget Sound Hlth Care Syst, Geriatr Res Educ & Clin Ctr, 1660 S Columbian Way, Seattle, WA 98108 USA

[2] Univ Washington, Sch Med, Dept Med, Div Gerontol & Geriatr Med, 1660 S Columbian Way, Seattle, WA 98108 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2016年 / 15卷 / 04期

关键词：

AMYLOID-BETA-PROTEIN; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; RECEPTOR-RELATED PROTEIN-1; MOUSE CEREBRAL PERICYTES; NECROSIS-FACTOR-ALPHA; SPINAL-CORD BARRIER; CEREBROSPINAL-FLUID; ALZHEIMERS-DISEASE; ENDOTHELIAL-CELLS; P-GLYCOPROTEIN;

D O I：

10.1038/nrd.2015.21

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

One of the biggest challenges in the development of therapeutics for central nervous system (CNS) disorders is achieving sufficient blood-brain barrier (BBB) penetration. Research in the past few decades has revealed that the BBB is not only a substantial barrier for drug delivery to the CNS but also a complex, dynamic interface that adapts to the needs of the CNS, responds to physiological changes, and is affected by and can even promote disease. This complexity confounds simple strategies for drug delivery to the CNS, but provides a wealth of opportunities and approaches for drug development. Here, I review some of the most important areas that have recently redefined the BBB and discuss how they can be applied to the development of CNS therapeutics.

引用

页码：275 / +

页数：18

共 175 条

[41] Pericytes are required for blood-brain barrier integrity during embryogenesis [J].

Daneman, Richard ;

Zhou, Lu ;

Kebede, Amanuel A. ;

Barres, Ben A. .

NATURE, 2010, 468 (7323) :562-U238

[42]

DAVSON H, 1957, P ROY SOC MED, V50, P963

[43] Permeability studies on in vitro blood-brain barrier models: Physiology, pathology, and pharmacology [J].

Deli, MA ;

Abraham, CS ;

Kataoka, Y ;

Niwa, M .

CELLULAR AND MOLECULAR NEUROBIOLOGY, 2005, 25 (01) :59-127

[44] DEFECTIVE GLUCOSE-TRANSPORT ACROSS THE BLOOD-BRAIN-BARRIER AS A CAUSE OF PERSISTENT HYPOGLYCORRHACHIA, SEIZURES, AND DEVELOPMENTAL DELAY [J].

DEVIVO, DC ;

TRIFILETTI, RR ;

JACOBSON, RI ;

RONEN, GM ;

BEHMAND, RA ;

HARIK, SI .

NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (10) :703-709

[45] HIV-I-induced production of endothelin-I in an in vitro model of the human blood-brain barrier [J].

Didier, N ;

Banks, WA ;

Créminon, C ;

Dereuddre-Bosquet, N ;

Mabondzo, A .

NEUROREPORT, 2002, 13 (09) :1179-1183

[46] Isolation of peptide transport system-6 from brain endothelial cells: therapeutic effects with antisense inhibition in Alzheimer and stroke models [J].

Dogrukol-Ak, Dilek ;

Kumar, Vijaya B. ;

Ryerse, Jan S. ;

Farr, Susan A. ;

Verma, Sulekha ;

Nonaka, Naoko ;

Nakamachi, Tomoya ;

Ohtaki, Hirokazu ;

Niehoff, Michael L. ;

Edwards, John C. ;

Shioda, Seiji ;

Morley, John E. ;

Banks, William A. .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2009, 29 (02) :411-422

[47] Brain pericytes increase the lipopolysaccharide-enhanced transcytosis of HIV-1 free virus across the in vitro blood-brain barrier: Evidence for cytokine-mediated pericyte-endothelial cell crosstalk [J].

Dohgu S. ;

Banks W.A. .

Fluids and Barriers of the CNS, 10 (1)

[48] Human Immunodeficiency Virus-1 Uses the Mannose-6-Phosphate Receptor to Cross the Blood-Brain Barrier [J].

Dohgu, Shinya ;

Ryerse, Jan S. ;

Robinson, Sandra M. ;

Banks, William A. .

PLOS ONE, 2012, 7 (06)

[49] Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF [J].

Dohgu, Shinya ;

Fleegal-DeMotta, Melissa A. ;

Banks, William A. .

JOURNAL OF NEUROINFLAMMATION, 2011, 8

[50] RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease [J].

Donahue, John E. ;

Flaherty, Stephanie L. ;

Johanson, Conrad E. ;

Duncan, John A., III ;

Silverberg, Gerald D. ;

Miller, Miles C. ;

Tavares, Rosemarie ;

Yang, Wentian ;

Wu, Qian ;

Sabo, Edmond ;

Hovanesian, Virginia ;

Stopa, Edward G. .

ACTA NEUROPATHOLOGICA, 2006, 112 (04) :405-415

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