Gum ghatti based hydrogel: Microwave synthesis, characterization, 5-Fluorouracil encapsulation and 'in vitro' drug release evaluation

被引：47

作者：

Pal, Pinki ^{[1
]}

Singh, Srikant Kumar ^{[1
]}

Mishra, Sumit ^{[1
]}

Pandey, Jay Prakash ^{[1
]}

Sen, Gautam ^{[1
]}

机构：

[1] Birla Inst Technol, Dept Chem, Ranchi 835215, Jharkhand, India

来源：

CARBOHYDRATE POLYMERS | 2019年 / 222卷

关键词：

Gum ghatti hydrogel; 5-Fluorouracil; Acrylamide; Microwave synthesis; Drug delivery; Hydrogel copolymer; G-PAM; DELIVERY; POLYSACCHARIDE; ALGINATE; DESIGN; ACID;

D O I：

10.1016/j.carbpol.2019.114979

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The release attributes of anticancer therapeutic embedded in programmable gum ghatti hydrogel matrices has been evaluated. Hydrogel has been programmed simply by adjusting the product composition (monomer-acrylamide and crosslinker-N, N Methylenebisacrylamide (MBAm)) to control mesh size during copolymerization of gum through microwave based technique. The synthesized system has been characterized for physicochemical traits and 'in-vitro' drug release in various physiological pH conditions by USP standard method. The degree of crosslinking analysed through equilibrium swelling ratio (ESR) has been correlated with release kinetics. The release profiles yielded from the measurements of cumulative drug delivery showed that the system with lower ESR included slower release rate than that of the system with higher ESR, consequently generated higher t(50) values. Additionally, the release rate rises with rise in pH milieu.

引用

页数：10

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