Evaluation of the Effect of Platelet-Rich Plasma on Alveolar Wound Healing in Rats

被引：1

作者：

Yamamoto, Marcos Kazuo ^{[1
]}

Novelli, Moacyr Domingos ^{[2
]}

Correa, Luciana ^{[2
]}

de Sousa, Suzana Cantanhede M. ^{[3
]}

Luz, Joao Gualberto C. ^{[1
]}

机构：

[1] Univ Sao Paulo, Sch Dent, Dept Oral & Maxillofacial Surg, Sao Paulo, Brazil

[2] Univ Sao Paulo, Sch Dent, Dept Gen Pathol, Sao Paulo, Brazil

[3] Univ Sao Paulo, Sch Dent, Dept Oral Pathol, Sao Paulo, Brazil

来源：

INTERNATIONAL JOURNAL OF MORPHOLOGY | 2017年 / 35卷 / 01期

关键词：

Tooth socket; Wound healing; Platelet-rich plasma; Animal experimentation; EXTRACTION SOCKETS; CLINICAL-TRIAL; REGENERATION; DEFECTS; DOGS;

D O I：

10.4067/S0717-95022017000100041

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Opinions about the clinical utility of platelet-rich plasma (PRP) vary, as a large number of experimental studies have questioned its efficacy. The purpose of this study was to evaluate the effects of PRP on experimental alveolar wound healing in rats. Fifty young adult male Wistar rats were divided in control and PRP groups and submitted to extraction of the right maxillary incisor. In the PRP group, blood was collected by cardiac puncture, and the socket was filled with a PRP gel. Animals were euthanized after 1, 3, 7, 14 and 30 days. Histological and histomorphometric analyses were performed at each experimental time point. Semiquantitative histological analysis showed that the PRP group exhibited significantly more collagen-matrix deposition and less bone-matrix formation in the socket than did the control group from 7 to 30 days. Histomorphometric analyses showed that the PRP group also exhibited lower bone-tissue areas than the control group at 7 (p=0.0250) and 14 days (p<0.0001), but at 30 days, no significant difference between the groups was observed. In the present study, PRP did not enhance alveolar wound healing, and PRP-treated rats exhibited low rates of bone deposition during the intermediate phases of alveolar socket repair.

引用

页码：251 / 258

页数：8

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