Regulation of the Na+/K+ ATPase by Klotho

被引：38

作者：

Sopjani, Mentor ^{[1
]}

Alesutan, Ioana ^{[1
]}

Deermaku-Sopjani, Miribane ^{[1
]}

Gu, Shuchen ^{[1
]}

Zelenak, Christine ^{[1
]}

Munoz, Carlos ^{[1
]}

Velic, Ana ^{[1
]}

Foeller, Michael ^{[1
]}

Rosenblatt, Kevin P. ^{[2
,3
]}

Kuro-o, Makoto ^{[4
]}

Lang, Florian ^{[1
]}

机构：

[1] Univ Tubingen, Inst Physiol, D-72076 Tubingen, Germany

[2] Univ Texas Med Branch 301, Dept Biochem & Mol Biol, Galveston, TX 77555 USA

[3] Univ Texas Med Branch 301, Dept Med, Galveston, TX 77555 USA

[4] Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA

来源：

FEBS LETTERS | 2011年 / 585卷 / 12期

关键词：

Pump activity; Sodium/potassium ATPase; Salt depletion; Protein stability; CALCIUM HOMEOSTASIS; TRPV5; CHANNEL; MICE; GENE; EXPRESSION; TRANSPORT; DEATH;

D O I：

10.1016/j.febslet.2011.05.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Klotho-hypomorphic (Klothohm) mice suffer from renal salt wasting and hypovolemia despite hyperaldosteronism. The present study explored the effect of Klotho on renal Na+/K+ ATPase activity. According to immunohistochemistry and confocal microscopy Na+/K+ ATPase protein abundance in isolated collecting ducts was lower in Klothohm mice than in their wild type littermates (Klotho(+/+)). Analysis with dual electrode voltage clamp recording showed that expression of Klotho in Xenopus oocytes increased the Na+/K+ ATPase pump current. Treatment of Xenopus oocytes with Klotho protein similarly increased the pump current. In conclusion, Klotho increases the membrane abundance and activity of the Na+/K+ ATPase. Decreased Na+/K+ ATPase activity could thus contribute to the volume-depletion of klothohm mice. Structured summary of protein interactions: Na+/K+ ATPase alpha-1 physically interacts with Klotho by anti bait coimmunoprecipitation (View interaction). (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1759 / 1764

页数：6

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