Molecule fluorescent probes for adenosine triphosphate imaging in cancer cells and in vivo

被引：53

作者：

Huang, Binghuan ^{[1
,2
]}

Liang, Bing ^{[1
,2
]}

Zhang, Renshuai ^{[1
,2
]}

Xing, Dongming ^{[1
,2
,3
]}

机构：

[1] Qingdao Univ, Affiliated Hosp, Qingdao 266071, Peoples R China

[2] Qingdao Univ, Qingdao Canc Inst, Qingdao 266071, Peoples R China

[3] Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China

来源：

COORDINATION CHEMISTRY REVIEWS | 2022年 / 452卷

基金：

中国博士后科学基金;

关键词：

Adenosine triphosphate; Fluorescent probes; ATP detection; Small-molecule probes; Water-soluble conjugated polymers; Fluorescence imaging; NUCLEOSIDE POLYPHOSPHATE DYNAMICS; MONITORING MITOCHONDRIAL ATP; OFF-ON RESPONSE; CONJUGATED-POLYMER; LIVING CELLS; LEVEL FLUCTUATION; AQUEOUS-SOLUTION; RECOGNITION; AGGREGATION; LYSOSOME;

D O I：

10.1016/j.ccr.2021.214302

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Adenosine triphosphate (ATP) is the primary energy source for all forms of work in cells, which is closely associated with cancers. Detection of ATP in specific intracellular compartment is crucial to precisely understand many biological processes. In recent years, a number of molecule fluorescent probes have been developed for sensing ATP in living organisms. However, there has not been a review that systematically summarizes the applications of fluorescent ATP probes in cancer cells according to the organelle-targeting ability of the probes. This review highlights fluorescent ATP probes based on small molecules and water-soluble conjugated polymers that have been successfully used to image ATP in specific areas of cancer cells and in vivo. These probes are classified according to their organelle-targeting abilities of the probes and the sensing mechanisms of fluorescent ATP probes are also emphasized. (C) 2021 Elsevier B.V. All rights reserved.

引用

页数：21

共 89 条

[61] Highly sensitive cell imaging "Off-On" fluorescent probe for mitochondria and ATP [J].