The neglected role of copper ions in wound healing

被引：157
作者：
Kornblatt, Allison Paige [1 ]
Nicoletti, Vincenzo Giuseppe [2 ,3 ,4 ]
Travaglia, Alessio [5 ]
机构：
[1] St Georges Univ, Sch Med, West Indies, Grenada
[2] Univ Catania, Dept Biomed & Biotechnol Sci, Viale Andrea Doria 6, I-95125 Catania, Italy
[3] Consorzio Interuniv, INBB, Sez Biomol, Viale Medaglie Oro 305, I-00136 Rome, Italy
[4] CIRCMSB, Via Celso Ulpiani 27, I-70125 Bari, Italy
[5] NYU, Ctr Neural Sci, 4 Washington Pl, New York, NY 10003 USA
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2016年 / 161卷
关键词：
Would healing; Copper; Nerve Growth Factor; Metal ion homeostasis; Inflammation; Angiogenesis; NERVE GROWTH-FACTOR; PROTECTS HUMAN KERATINOCYTES; MATRIX-METALLOPROTEINASES; MAST-CELLS; IN-VITRO; TERMINAL DIFFERENTIATION; DERMAL FIBROBLASTS; FACTOR EXPRESSION; PRESSURE ULCERS; BASIC SCIENCE;
D O I：
10.1016/j.jinorgbio.2016.02.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Wound healing is a complex biological process that aims to repair damaged tissue. Even though many biological and biochemical mechanisms associated with the steps of physiological wound healing are known, there is still significant morbidity and mortality due to dysregulation of physiological mechanisms. It might be useful to revise the activity of old players and their links with new, often neglected, molecular entities. This review revises new findings supporting the hypothesis that copper ions regulate the activity and/or the expression of proteins crucially involved in the wound repair process A better understanding of these interactions might suggest potential new targets for therapeutic intervention on scars or non-healing wounds. (C) 2016 Elsevier Inc. All rights reserved.
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页码：1 / 8
页数：8
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