NK cell recognition

被引:2175
作者
Lanier, LL [1 ]
机构
[1] Univ Calif San Francisco, Sch Med, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Sch Med, Canc Res Inst, San Francisco, CA 94143 USA
关键词
innate immunity; immune receptors; signal transduction;
D O I
10.1146/annurev.immunol.23.021704.115526
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The integrated processing of signals transduced by activating and inhibitory cell surface receptors regulates NK cell effector functions. Here, I review the structure, function, and ligand specificity of the receptors responsible for NK cell recognition.
引用
收藏
页码:225 / 274
页数:50
相关论文
共 369 条
[71]  
Cosman D, 2001, IMMUNITY, V14, P123, DOI 10.1016/S1074-7613(01)00095-4
[72]   Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2Kb [J].
Dam, J ;
Guan, RJ ;
Natarajan, K ;
Dimasi, N ;
Chlewicki, LK ;
Kranz, DM ;
Schuck, P ;
Margulies, DH ;
Mariuzza, RA .
NATURE IMMUNOLOGY, 2003, 4 (12) :1213-1222
[73]  
DANDREA A, 1995, J IMMUNOL, V155, P2306
[74]   Murine cytomegalovirus is regulated by a discrete subset of natural killer cells reactive with monoclonal antibody to Ly49H [J].
Daniels, KA ;
Devora, G ;
Lai, WC ;
O'Donnell, CL ;
Bennett, M ;
Welsh, RM .
JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (01) :29-44
[75]   A peptide from heat shock protein 60 is the dominant peptide bound to Qa-1 in the absence of the MHC class Ia leader sequence peptide QDM [J].
Davies, A ;
Kalb, S ;
Liang, BT ;
Aldrich, CJ ;
Lemonnier, FA ;
Jiang, H ;
Cotter, R ;
Soloski, MJ .
JOURNAL OF IMMUNOLOGY, 2003, 170 (10) :5027-5033
[76]   Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants [J].
Davies, SM ;
Ruggieri, L ;
DeFor, T ;
Wagner, JE ;
Weisdorf, DJ ;
Miller, JS ;
Velardi, A ;
Blazar, BR .
BLOOD, 2002, 100 (10) :3825-3827
[77]   The human natural killer cell immune synapse [J].
Davis, DM ;
Chiu, I ;
Fassett, M ;
Cohen, GB ;
Mandelboim, O ;
Strominger, JL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :15062-15067
[78]   Expression of CD94/NKG2-A on human T lymphocytes is induced by IL-12: Implications for adoptive immunotherapy [J].
Derre, L ;
Corvaisier, M ;
Pandolfino, MC ;
Diez, E ;
Jotereau, F ;
Gervois, N .
JOURNAL OF IMMUNOLOGY, 2002, 168 (10) :4864-4870
[79]   Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages [J].
Diefenbach, A ;
Jamieson, AM ;
Liu, SD ;
Shastri, N ;
Raulet, DH .
NATURE IMMUNOLOGY, 2000, 1 (02) :119-126
[80]   A novel ligand for the NKG2D receptor activates NK cells and macrophages and induces tumor immunity [J].
Diefenbach, A ;
Hsia, JK ;
Hsiung, MYB ;
Raulet, DH .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (02) :381-391