Epidemiological, genetic, and clinical characterization by age of newly diagnosed acute myeloid leukemia based on an academic population-based registry study (AMLSG BiO)

被引：129

作者：

Nagel, Gabriele ^{[1
]}

Weber, D. ^{[2
]}

Fromm, E. ^{[1
]}

Erhardt, S. ^{[1
]}

Luebbert, M. ^{[3
]}

Fiedler, W. ^{[4
]}

Kindler, T. ^{[5
]}

Krauter, J. ^{[6
]}

Brossart, P. ^{[7
]}

Kuendgen, A. ^{[8
]}

Salih, H. R. ^{[9
]}

Westermann, J. ^{[10
]}

Wulf, G. ^{[11
]}

Hertenstein, B. ^{[12
]}

Wattad, M. ^{[13
]}

Goetze, K. ^{[14
]}

Kraemer, D. ^{[15
]}

Heinicke, T. ^{[16
]}

Girschikofsky, M. ^{[17
]}

Derigs, H. G. ^{[18
]}

Horst, H. A. ^{[19
]}

Rudolph, C. ^{[2
]}

Heuser, M. ^{[20
]}

Goehring, G. ^{[21
]}

Teleanu, V. ^{[2
]}

Bullinger, L. ^{[2
]}

Thol, F. ^{[20
]}

Gaidzik, V. I. ^{[2
]}

Paschka, P. ^{[2
]}

Doehner, K. ^{[2
]}

Ganser, A. ^{[20
]}

Doehner, Hartmut ^{[2
]}

Schlenk, R. F. ^{[2
,22
]}

机构：

[1] Univ Ulm, Inst Epidemiol & Med Biometry, Helmholtzstr 22, D-89081 Ulm, Germany

[2] Univ Hosp Ulm, Dept Internal Med 3, Albert Einstein Allee 23, D-89081 Ulm, Germany

[3] Univ Hosp Freiburg, Dept Internal Med 1, Fac Med, Freiburg, Germany

[4] Univ Hosp Hamburg Eppendorf, Dept Internal Med 2, Hamburg, Germany

[5] Univ Med Ctr Mainz, Dept Internal Med 3, Mainz, Germany

[6] Hosp Braunschweig, Dept Internal Med 3, Braunschweig, Germany

[7] Univ Hosp Bonn, Dept Internal Med 3, Bonn, Germany

[8] Univ Hosp Dusseldorf, Dept Hematol Oncol & Clin Immunol, Dusseldorf, Germany

[9] Univ Hosp Tubingen, Dept Internal Med 2, Tubingen, Germany

[10] Charite Campus Virchow Clin, Dept Hematol Oncol & Tumor Immunol, Berlin, Germany

[11] Univ Hosp Gottingen, Dept Hematol & Oncol, Gottingen, Germany

[12] Hosp Bremen Mitte, Dept Internal Med 1, Bremen, Germany

[13] Hosp Essen Werden, Dept Hematol & Oncol, Essen, Germany

[14] Univ Hosp, Klinikum Rechts Isar, Dept Internal Med 3, Munich, Germany

[15] Hosp Oldenburg, Dept Hematol & Oncol, Oldenburg, Germany

[16] Univ Hosp Magdeburg, Dept Hematol & Oncol, Magdeburg, Germany

[17] Hosp Elisabethinen Linz, Dept Hematol & Oncol, Linz, Austria

[18] Hosp Frankfurt Hoechst, Dept Internal Med 3, Frankfurt, Germany

[19] Univ Hosp Schleswig Holstein, Dept Internal Med 2, Kiel, Germany

[20] Hannover Med Sch, Dept Hematol Hemostasis Oncol & Stem Cell Transpl, Hannover, Germany

[21] Hannover Med Sch, Inst Human Genet, Hannover, Germany

[22] Natl Ctr Tumor Dis, NCT Trial Ctr, Heidelberg, Germany

来源：

ANNALS OF HEMATOLOGY | 2017年 / 96卷 / 12期

关键词：

Epidemiology; Genetics; Older age; AML; Registry; INTERNATIONAL EXPERT PANEL; OLDER PATIENTS; CELL TRANSPLANTATION; SURVIVAL; ADULTS; MUTATIONS; CANCER; RECOMMENDATIONS; CLASSIFICATION; MALIGNANCIES;

D O I：

10.1007/s00277-017-3150-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe genetic and clinical characteristics of acute myeloid leukemia (AML) patients according to age from an academic population-based registry. Adult patients with newly diagnosed AML at 63 centers in Germany and Austria were followed within the AMLSG BiO registry (NCT01252485). Between January 1, 2012, and December 31, 2014, data of 3525 patients with AML (45% women) were collected. The median age was 65 years (range 18-94). The comparison of age-specific AML incidence rates with epidemiological cancer registries revealed excellent coverage in patients < 70 years old and good coverage up to the age of 80. The distribution according to the European LeukemiaNet (ELN) risk categorization from 2010 was 20% favorable, 31% intermediate-1, 28% intermediate-2, and 21% adverse. With increasing age, the relative but not the absolute prevalence of patients with ELN favorable and intermediate-1 risk (p < 0.001), with activating FLT3 mutations (p < 0.001), with ECOG performance status < 2 (p < 0.001), and with HCT-CI comorbidity index < 3 (p < 0.001) decreased. Regarding treatment, obesity and favorable risk were associated with an intensive treatment, whereas adverse risk, higher age, and comorbidity index > 0 were associated with non-intensive treatment or best supportive care. The AMLSG BiO registry provides reliable population-based distributions of genetic, clinical, and treatment characteristics according to age.

引用

页码：1993 / 2003

页数：11

共 35 条

[21] Emerging strategies for the treatment of older patients with acute myeloid leukemia [J].

Sanz, Miguel A. ;

Iacoboni, Gloria ;

Montesinos, Pau ;

Venditti, Adriano .

ANNALS OF HEMATOLOGY, 2016, 95 (10) :1583-1593

[22]

SCHLENK RF, 2016, BLOOD, V128

[23] Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia [J].

Schlenk, Richard F. ;

Doehner, Konstanze ;

Krauter, Juergen ;

Froehling, Stefan ;

Corbacioglu, Andrea ;

Bullinger, Lars ;

Habdank, Marianne ;

Spaeth, Daniela ;

Morgan, Michael ;

Benner, Axel ;

Schlegelberger, Brigitte ;

Heil, Gerhard ;

Ganser, Arnold ;

Doehner, Hartmut .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (18) :1909-1918

[24] Genomic applications in the clinic: use in treatment paradigm of acute myeloid leukemia [J].

Schlenk, Richard F. ;

Doehner, Hartmut .

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 2013, :324-330

[25] The value of allogeneic and autologous hematopoietic stem cell transplantation in prognostically favorable acute myeloid leukemia with double mutant CEBPA [J].

Schlenk, Richard F. ;

Taskesen, Erdogan ;

van Norden, Yvette ;

Krauter, Juergen ;

Ganser, Arnold ;

Bullinger, Lars ;

Gaidzik, Verena I. ;

Paschka, Peter ;

Corbacioglu, Andrea ;

Goehring, Gudrun ;

Kuendgen, Andrea ;

Held, Gerhard ;

Goetze, Katharina ;

Vellenga, Edo ;

Kuball, Juergen ;

Schanz, Urs ;

Passweg, Jakob ;

Pabst, Thomas ;

Maertens, Johan ;

Ossenkoppele, Gert J. ;

Delwel, Ruud ;

Doehner, Hartmut ;

Cornelissen, Jan J. ;

Doehner, Konstanze ;

Lowenberg, Bob .

BLOOD, 2013, 122 (09) :1576-1582

[26] Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B [J].

Schlenk, Richard F. ;

Doehner, Konstanze ;

Kneba, Michael ;

Goetze, Katharina ;

Hartmann, Frank ;

del Valle, Francesco ;

Kirchen, Heinz ;

Koller, Elisabeth ;

Fischer, Joerg T. ;

Bullinger, Lars ;

Habdank, Marianne ;

Spaeth, Daniela ;

Groner, Siija ;

Krebs, Bernhard ;

Kayser, Sabine ;

Corbacioglu, Andrea ;

Anhalt, Andreas ;

Benner, Axel ;

Froehling, Stefan ;

Doehner, Hartmut .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 (01) :54-60

[27] Age-dependent frequencies of NPM1 mutations and FLT3-ITD in patients with normal karyotype AML (NK-AML) [J].

Schneider, Friederike ;

Hoster, Eva ;

Schneider, Stephanie ;

Dufour, Annika ;

Benthaus, Tobias ;

Kakadia, Purvi M. ;

Bohlander, Stefan K. ;

Braess, Jan ;

Heinecke, Achim ;

Sauerland, Maria C. ;

Berdel, Wolfgang E. ;

Buechner, Thomas ;

Woermann, Bernhard J. ;

Feuring-Buske, Michaela ;

Buske, Christian ;

Creutzig, Ursula ;

Thiede, Christian ;

Zwaan, Michel C. ;

van den Heuvel-Eibrink, Marry M. ;

Reinhardt, Dirk ;

Hiddemann, Wolfgang ;

Spiekermann, Karsten .

ANNALS OF HEMATOLOGY, 2012, 91 (01) :9-18

[28] Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT [J].

Sorror, ML ;

Maris, MB ;

Storb, R ;

Baron, F ;

Sandmaier, BM ;

Maloney, DG ;

Storer, B .

BLOOD, 2005, 106 (08) :2912-2919

[29]

Statistisches Bundesamt, 2015, BEV 2012 2014

[30]

Stone RM., 2015, Blood, V126, P6, DOI DOI 10.1182/blood.V126.23.6.6

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