Antitumor and immunomodulatory activity of arabinoxylans: A major constituent of wheat bran

被引：96

作者：

Cao, Li ^{[2
,3
]}

Liu, Xiuzhen ^{[2
,3
]}

Qian, Tianxiu ^{[2
,3
]}

Sun, Guibo ^{[2
,3
]}

Guo, Yan ^{[2
,3
]}

Chang, Fengjin ^{[2
,3
]}

Zhou, Sumei ^{[1
]}

Sun, Xiaobo ^{[2
,3
]}

机构：

[1] Chinese Acad Agr Sci, Inst Agrofood Sci & Technol, Beijing 100193, Peoples R China

[2] Peking Union Med Coll, Beijing 100193, Peoples R China

[3] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2011年 / 48卷 / 01期

关键词：

Wheat bran; Arabinoxylans; S180 tumor mice; Antitumor; Immunomodulatory; DIETARY FIBER; TRITERPENOID FRACTIONS; COLON-CANCER; RHIZOMES;

D O I：

10.1016/j.ijbiomac.2010.10.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We aimed to investigate the antitumor activity of wheat bran arabinoxylans, including the role of its immunostimulatory effect. In S180 tumor-bearing mice arabinoxylan administration significantly inhibited the growth of mouse transplantable tumors and remarkably promoted thymus and spleen indexes, splenocyte proliferation, natural killer cell and macrophage phagocytosis activity, interleukin 2 production, and delayed-type hypersensitivity reaction. In addition, it increased peripheral leukocyte count, and bone-marrow cellularity in tumor-bearing mice. As the antitumor activity of arabinoxylans may be mediated via the improvement in the immune response, they can be considered an antitumor agent with immunomodulatory activity. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：160 / 164

页数：5

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