Molecular docking analysis of flavonoids with aldose reductase

被引：6

作者：

Kannayiram, Kasthuri ^{[1
]}

Umapathy, Vidhya Rekha ^{[2
]}

Chamundeswari, Y. ^{[3
]}

Fathima, J. H. ^{[4
]}

Govindan, Ramajayam ^{[5
]}

Palanisamy, Chella Perumal ^{[6
]}

Veeraraghavan, Vishnu Priya ^{[7
]}

Jayaraman, Selvaraj ^{[7
]}

Rajagopal, Ponnulakshmi

机构：

[1] Tagore Med Coll & Hosp, Dept Biochem, Chennai, Tamil Nadu, India

[2] Sree Balaji Dent Coll & Hosp, Dept Publ Hlth Dent, Chennai 600100, Tamil Nadu, India

[3] Dr MGR Educ & Res Inst, Allied Hlth Sci, Dept Biochem, Chennai, Tamil Nadu, India

[4] Ragas Dent Coll & Hosp, Dept Oral & Maxillofacial Pathol, Chennai, Tamil Nadu, India

[5] Madurai Med Coll, Multi Disciplinary Res Unit, Madurai, Tamil Nadu, India

[6] Qilu Univ Technol, Shandong Acad Sci, Coll Food Sci & Engn, State Key Lab Biobased Mat & Green Papermaking, Jinan 250353, Peoples R China

[7] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Dent Coll & Hosp, Dept Biochem, Chennai, Tamil Nadu, India

来源：

BIOINFORMATION | 2022年 / 18卷 / 03期

关键词：

Diabetes; molecular docking; aldose reductase; flavonoids; IN-VIVO; GLYCOSIDES;

D O I：

10.6026/97320630018180

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Diabetes mellitus is a group of metabolic disorders that has risen to become the third most common cause in humans in recent years. The development of new bioactive substances from natural sources is a relatively new area. Flavonoids are believed to have a variety of beneficial properties in nature, including anti-inflammatory, antimicrobial, anticancer, antioxidant, neuroprotective, and anti-HIV properties. 15 naturally occurring flavonoids docked with the selected target aldose reductase. We report the optimal binding of Acumitin, Agathisflavone, Agehoustin B, and alpha-Toxicarol with aldose reductase for further consideration in drug discovery for T2DM.

引用

页码：180 / 183

页数：4

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