Interaction between BDNF and serotonin: Role in mood disorders

被引：590

作者：

Martinowich, Keri

Lu, Bai

机构：

[1] Natl Inst Hlth, NIMH, Mood & Anxiety Disorders Program, Bethesda, MD USA

[2] Natl Inst Hlth, NICHD, Sect Neural Dev & Plascticity, Bethesda, MD USA

来源：

NEUROPSYCHOPHARMACOLOGY | 2008年 / 33卷 / 01期

关键词：

depression; anxiety; p75(NTR); TrkB; 5-HTT; SSRI;

D O I：

10.1038/sj.npp.1301571

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain-derived neurotrophic factor ( BDNF) and serotonin ( 5-hydroxytryptamine, 5-HT) are two seemingly distinct signaling systems that play regulatory roles in many neuronal functions including survival, neurogenesis, and synaptic plasticity. A common feature of the two systems is their ability to regulate the development and plasticity of neural circuits involved in mood disorders such as depression and anxiety. BDNF promotes the survival and differentiation of 5-HT neurons. Conversely, administration of antidepressant selective serotonin reuptake inhibitors ( SSRIs) enhances BDNF gene expression. There is also evidence for synergism between the two systems in affective behaviors and genetic epitasis between BDNF and the serotonin transporter genes.

引用

页码：73 / 83

页数：11

共 131 条

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