Cutaneous angiosarcoma. New aspects

被引：3

作者：

Brenn, T. ^{[1
,2
]}

机构：

[1] Western Gen Hosp, Abt Pathol, Edinburgh EH4 2XU, Midlothian, Scotland

[2] Univ Edinburgh, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

PATHOLOGE | 2015年 / 36卷 / 01期

关键词：

Differential diagnosis; Endothelial cell differentiation; Immunophenotypic features; Molecular genetic characteristics; Anti-ERG antibody; ATYPICAL VASCULAR-LESIONS; RADIATION-ASSOCIATED ANGIOSARCOMA; ANTI-MYC IMMUNOHISTOCHEMISTRY; GRANULAR-CELL ANGIOSARCOMA; STEWART-TREVES-SYNDROME; EPITHELIOID SARCOMA; BREAST; AMPLIFICATION; EXPRESSION; FEATURES;

D O I：

10.1007/s00292-014-2002-3

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Cutaneous angiosarcoma is an aggressive endothelial cell neoplasm with a high associated mortality. Reliable and confident diagnosis is necessary but frequently challenging due to the wide morphological spectrum and broad differential diagnosis of the disease. Furthermore, the final diagnosis often relies on immunohistochemical evidence of endothelial cell differentiation which is further complicated by the lack of sensitivity and specificity of conventional endothelial cell markers. The following article outlines the clinical and histological spectrum of cutaneous angiosarcoma with emphasis on novel findings relating to immunohistochemistry and molecular genetics in the context of the relevant differential diagnosis.

引用

页码：70 / 77

页数：8