Polymer-supported silyl enol ethers. Synthesis and reactions with imines for the preparation of an amino alcohol library

被引：71

作者：

Kobayashi, S

Hachiya, I

Suzuki, S

Moriwaki, M

机构：

[1] Department of Applied Chemistry, Faculty of Science, Science University of Tokyo (SUT), Tokyo 162, Kagurazaka, Shinjuku-ku

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 16期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/0040-4039(96)00435-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polymer-supported silyl enol ethers (thioketene silyl acetals) were prepared from chloromethyl copoly-(styrene-1%-divinylbenzene) resin. The silyl enol ethers reacted with imines in the presence of a catalytic amount of scandium triflate (Sc(OTf)(3)) to afford beta-amino thioesters, which were reduced to amino alcohols in good yields. These reactions provide a convenient method for the preparation of an amino alcohol library. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2809 / 2812

页数：4

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