Beth Levine's Legacy: From the Discovery of BECN1 to Therapies. A Mentees' Perspective

被引：2

作者：

An, Zhenyi ^{[1
]}

Chiang, Wei-Chung ^{[2
]}

Fernandez, Alvaro F. ^{[3
]}

Franco, Luis H. ^{[4
]}

He, Congcong ^{[5
]}

Huang, Shu-Yi ^{[6
]}

Lee, Eunmyong ^{[7
]}

Liu, Yang ^{[8
,9
]}

Sebti, Salwa ^{[10
]}

Shoji-Kawata, Sanae ^{[11
]}

Sirasanagandla, Shyam ^{[12
]}

Wang, Richard C. ^{[13
]}

Wei, Yongjie ^{[14
]}

Zhao, Yuting ^{[15
]}

Vega-Rubin-de-Celis, Silvia ^{[16
]}

机构：

[1] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[2] Natl Yang Ming Chiao Tung Univ, Coll Life Sci, Inst Biochem & Mol Biol, Taipei, Taiwan

[3] Univ Oviedo, Inst Univ Oncol IUOPA, Inst Invest Sanitaria Principado Asturias ISPA, Dept Bioquim & Biol Mol, Oviedo, Spain

[4] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, Belo Horizonte, MG, Brazil

[5] Northwestern Univ, Feinberg Sch Med, Dept Cell & Dev Biol, Chicago, IL 60611 USA

[6] Natl Taiwan Univ Hosp, Dept Med Res, Taipei, Taiwan

[7] InnoCure Therapeut Inc, Gyeonggi Do, South Korea

[8] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Integrat Biol & Pharmacol, Houston, TX 77030 USA

[9] Univ Texas Southwestern Med Ctr Dallas, Dept Integrat Biol & Pharmacol, McGovern Med Sch, Dallas, TX 75390 USA

[10] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX USA

[11] Nishi Nara Cent Hosp, Dept Pharm, Nara, Japan

[12] St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA

[13] Univ Texas Southwestern Med Ctr Dallas, Dept Dermatol, Dallas, TX USA

[14] Guangzhou Med Univ, Canc Res Inst, Guangzhou, Peoples R China

[15] Northwest A&F Univ, Inst Future Agr, Yangling, Shaanxi, Peoples R China

[16] Univ Duisburg Essen, Essen Univ Hosp, Inst Cell Biol Canc Res, Essen, Germany

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷

基金：

美国国家卫生研究院;

关键词：

BECN1; macroautophagy; selective autophagy; cancer; aging; metabolism; infectious diseases; Beth Levine; AUTOPHAGY GENES PROTECT; LIFE-SPAN EXTENSION; BCL-X-L; BECLIN; SELECTIVE AUTOPHAGY; CARGO RECOGNITION; MOLECULAR-BASIS; BH3; DOMAIN; CELL; PHOSPHORYLATION;

D O I：

10.3389/fcell.2022.891332

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

With great sadness, the scientific community received the news of the loss of Beth Levine on 15 June 2020. Dr. Levine was a pioneer in the autophagy field and work in her lab led not only to a better understanding of the molecular mechanisms regulating the pathway, but also its implications in multiple physiological and pathological conditions, including its role in development, host defense, tumorigenesis, aging or metabolism. This review does not aim to provide a comprehensive view of autophagy, but rather an outline of some of the discoveries made by the group of Beth Levine, from the perspective of some of her own mentees, hoping to honor her legacy in science.

引用

页数：15