Photoadaptation in Neurospora by Competitive Interaction of Activating and Inhibitory LOV Domains

被引：129

作者：

Malzahn, Erik ^{[1
]}

Ciprianidis, Stilianos ^{[1
]}

Kaldi, Krisztina ^{[2
]}

Schafmeier, Tobias ^{[1
]}

Brunner, Michael ^{[1
]}

机构：

[1] Heidelberg Univ, Biochem Ctr, D-69120 Heidelberg, Germany

[2] Semmelweis Univ, Dept Physiol, H-1444 Budapest, Hungary

来源：

CELL | 2010年 / 142卷 / 05期

关键词：

BLUE-LIGHT PHOTORECEPTOR; CIRCADIAN GENE-EXPRESSION; CLOCK GENE; TRANSCRIPTION FACTOR; BINDING DOMAINS; WHITE COLLAR-1; PROTEIN; TRANSFORMATION; ORGANIZATION; ARABIDOPSIS;

D O I：

10.1016/j.cell.2010.08.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Light responses and photoadaptation of Neurospora depend on the photosensory light-oxygen-voltage (LOV) domains of the circadian transcription factor White Collar Complex (WCC) and its negative regulator VIVID (VVD). We found that light triggers LOV-mediated dimerization of the WCC. The activated WCC induces expression of VVD, which then disrupts and inactivates the WCC homodimers by the competitive formation of WCC-VVD heterodimers, leading to photoadaptation. During the day, expression levels of VVD correlate with light intensity, allowing photoadaptation over several orders of magnitude. At night, previously synthesized VVD serves as a molecular memory of the brightness of the preceding day and suppresses responses to light cues of lower intensity. We show that VVD is essential to discriminate between day and night, even in naturally ambiguous photoperiods with moonlight.

引用

页码：762 / 772

页数：11

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