The application of oncolytic viruses in cancer therapy

被引：4

作者：

Gao, Yang ^{[1
]}

Wu, Yan ^{[1
]}

Huan, Tian ^{[1
]}

Wang, Xiaoyan ^{[2
]}

Xu, Jun ^{[3
]}

Xu, Qinggang ^{[1
]}

Yu, Feng ^{[1
]}

Shi, Haifeng ^{[1
]}

机构：

[1] Jiangsu Univ, Sch Life Sci, 301 Xuefu Rd, Zhenjiang, Jiangsu, Peoples R China

[2] First Peoples Hosp Sugian, Dept Gastroenterol, Sugian, Jiangsu, Peoples R China

[3] Capital Med Univ, Dept Cognit Neurol, China Natl Clin Res Ctr Neurol Dis NCRC ND, Beijing Tian Tan Hosp, Beijing, Peoples R China

来源：

BIOTECHNOLOGY LETTERS | 2021年 / 43卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Oncolytic virus; Cancer therapy; Immune response; Molecular mechanism; NEWCASTLE-DISEASE VIRUS; TALIMOGENE LAHERPAREPVEC; CELLS; REPLICATION; EXPRESSION; ANTIBODIES; REOVIRUS; IMPROVES;

D O I：

10.1007/s10529-021-03173-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Oncolytic therapy is a treatment method used to directly combat tumor cells by modifying the genes of naturally occurring low pathogenic viruses to form "rhizobia" virus. By taking the advantage of abnormal signal pathways in cancer cells, it selectively replicates in tumor cells leading to tumor cell lysis and death. At present, clinical studies widely employ biomolecular technology to transform oncolytic viruses to exert stronger oncolytic effects and reduce their adverse reactions. This review summarizes the current progresses and the molecular mechanism of oncolytic viruses towards tumor treatment and management.

引用

页码：1945 / 1954

页数：10

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