New steroidal saponins from the rhizomes of Paris delavayi and their cytotoxicity

被引：22
作者：
Liu, Yang [1 ,2 ]
Tian, Xiangrong [3 ]
Hua, Dong [1 ]
Cheng, Guang [4 ]
Wang, Kaixing [5 ]
Zhang, Lihan [6 ,7 ]
Tang, Haifeng [1 ]
Wang, Minchang [6 ,7 ]
机构：
[1] Fourth Mil Med Univ, Sch Pharm, Inst Mat Med, Xian 710032, Peoples R China
[2] Fourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian 710032, Peoples R China
[3] Northwest A&F Univ, Coll Plant Protect, Yangling 712100, Peoples R China
[4] Fourth Mil Med Univ, Xijing Inst Clin Neurosci, Dept Neurosurg, Xian 710032, Peoples R China
[5] Fourth Mil Med Univ, Sch Nursing, Xian 710032, Peoples R China
[6] State Key Lab Fluorine & Nitrogen Chem, Xian 710065, Peoples R China
[7] Xian Modern Chem Res Inst, Xian 710065, Peoples R China
来源：
FITOTERAPIA | 2016年 / 111卷
基金：
中国国家自然科学基金;
关键词：
Paris delavayi; Liliaceae; Furostanol saponin; Spirostanol saponin; Padelaoside; Cytotoxicity; CHEMICAL-CONSTITUENTS; TRITERPENOID SAPONINS; VAR; CHINENSIS; POLYPHYLLA; GLYCOSIDES;
D O I：
10.1016/j.fitote.2016.04.018
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new furostanol saponins, named padelaosides C-F (1-4), together with four known spirostanol saponins 58 were isolated from the rhizomes of Paris delavayi Franchet. Their structures were elucidated on the baSis of extensive spectroscopic analysis and chemical evidences. The discovery of the new compounds 1-4 extended the diversity and complexity of this furostanol saponin family. The cytotoxicity of all the saponins was evaluated for their cytotoxicity against human glioblastoma U87MG and human hepatocellular carcinoma Hep-G2 cell lines. The known spirostanol saponins 7 and 8 exhibited notable cytotoxicity against the two tumor cell lines with IC50 values of 1.13 and 3.42 mu M, respectively, while the new furostanol saponins 3 and 4 showed moderate cytotoxicity with IC50 values of 15.28 to 16.981 mu M. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：130 / 137
页数：8
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