Oxidative stress as a therapeutic target for the prevention and treatment of early age-related macular degeneration

被引：38

作者：

Jabbehdari, Sayena ^{[1
]}

Handa, James T. ^{[2
]}

机构：

[1] Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL USA

[2] Johns Hopkins Sch Med, Wilmer Eye Inst, Baltimore, MD 21287 USA

来源：

SURVEY OF OPHTHALMOLOGY | 2021年 / 66卷 / 03期

关键词：

aging; age-related macular degeneration; antioxidant therapy; oxidative stress; RETINAL-PIGMENT EPITHELIUM; REACTIVE OXYGEN; DIETARY-FAT; CIGARETTE-SMOKING; PHYSICAL-ACTIVITY; GENE-EXPRESSION; BETA-CAROTENE; RPE CELLS; ASSOCIATION; PROGRESSION;

D O I：

10.1016/j.survophthal.2020.09.002

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Age-related macular degeneration, the leading cause of irreversible visual loss among older adults in developed countries, is a chronic, multifactorial, and progressive disease with the development of painless, central vision loss. Retinal pigment epithelial cell dysfunction is a core change in age-related macular degeneration that results from aging and the accu-mulated effects of genetic and environmental factors that, in part, is both caused by and leads to oxidative stress. In this review, we describe the role of oxidative stress, the cytoprotective oxidative stress pathways, and the impact of oxidative stress on critical cellular processes involved in age-related macular degeneration pathobiology. We also offer targeted therapy that may define how antioxidant therapy can either prevent or improve specific stages of age-related macular degeneration. (c) 2020 Elsevier Inc. All rights reserved.

引用

页码：423 / 440

页数：18

共 183 条

[41] Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1/VEGF Signaling under Hypoxia [J].

Chen, Meng-Chuan ;

Hsu, Wen-Lin ;

Hwang, Pai-An ;

Chou, Tz-Chong .

MARINE DRUGS, 2015, 13 (07) :4436-4451

[42] Bruch's membrane and choroidal macrophages in early and advanced age-related macular degeneration [J].

Cherepanoff, S. ;

McMenamin, P. ;

Gillies, M. C. ;

Kettle, E. ;

Sarks, S. H. .

BRITISH JOURNAL OF OPHTHALMOLOGY, 2010, 94 (07) :918-925

[43] Long-Term Effects of Vitamins C and E, β-Carotene, and Zinc on Age-related Macular Degeneration AREDS Report No. 35 [J].

Chew, Emily Y. ;

Clemons, Traci E. ;

Agron, Elvira ;

Sperduto, Robert D. ;

SanGiovanni, John Paul ;

Kurinij, Natalie ;

Davis, Matthew D. .

OPHTHALMOLOGY, 2013, 120 (08) :1604-+

[44] The Relationship of Major American Dietary Patterns to Age-Related Macular Degeneration [J].

Chiu, Chung-Jung ;

Chang, Min-Lee ;

Zhang, Fang Fang ;

Li, Tricia ;

Gensler, Gary ;

Schleicher, Molly ;

Taylor, Allen .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2014, 158 (01) :118-127

[45]

Cho E, 2001, AM J CLIN NUTR, V73, P209

[46] Induction of Autophagy and Cell Death by Tamoxifen in Cultured Retinal Pigment Epithelial and Photoreceptor Cells [J].

Cho, Kyung Sook ;

Yoon, Young Hee ;

Choi, Jeong A. ;

Lee, Sook-Jeong ;

Koh, Jae-Young .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2012, 53 (09) :5344-5353

[47] Lutein improves cell viability and reduces Alu RNA accumulation in hydrogen peroxide challenged retinal pigment epithelial cells [J].

Chong, You Sheng ;

Mai, Chun Wai ;

Leong, Chee Onn ;

Wong, Lai Chun .

CUTANEOUS AND OCULAR TOXICOLOGY, 2018, 37 (01) :52-60

[48] The Role of Immunosenescence in Neurodegenerative Diseases [J].

Costantini, Erica ;

D'Angelo, Chiara ;

Reale, Marcella .

MEDIATORS OF INFLAMMATION, 2018, 2018

[49] Biochemical functions of coenzyme Q10 [J].

Crane, FL .

JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2001, 20 (06) :591-598

[50] CIGARETTE-SMOKE OXIDATION OF HUMAN PLASMA CONSTITUENTS [J].

CROSS, CE ;

ONEILL, CA ;

REZNICK, AZ ;

HU, ML ;

MARCOCCI, L ;

PACKER, L ;

FREI, B ;

LAKE, R ;

DISILVESTRO, R ;

ADLKOFER, F ;

PRYOR, W .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES, 1993, 686 :72-90

← 1 2 3 4 5 6 7 8 9 10 →