Oxidative stress as a therapeutic target for the prevention and treatment of early age-related macular degeneration

被引：38

作者：

Jabbehdari, Sayena ^{[1
]}

Handa, James T. ^{[2
]}

机构：

[1] Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL USA

[2] Johns Hopkins Sch Med, Wilmer Eye Inst, Baltimore, MD 21287 USA

来源：

SURVEY OF OPHTHALMOLOGY | 2021年 / 66卷 / 03期

关键词：

aging; age-related macular degeneration; antioxidant therapy; oxidative stress; RETINAL-PIGMENT EPITHELIUM; REACTIVE OXYGEN; DIETARY-FAT; CIGARETTE-SMOKING; PHYSICAL-ACTIVITY; GENE-EXPRESSION; BETA-CAROTENE; RPE CELLS; ASSOCIATION; PROGRESSION;

D O I：

10.1016/j.survophthal.2020.09.002

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Age-related macular degeneration, the leading cause of irreversible visual loss among older adults in developed countries, is a chronic, multifactorial, and progressive disease with the development of painless, central vision loss. Retinal pigment epithelial cell dysfunction is a core change in age-related macular degeneration that results from aging and the accu-mulated effects of genetic and environmental factors that, in part, is both caused by and leads to oxidative stress. In this review, we describe the role of oxidative stress, the cytoprotective oxidative stress pathways, and the impact of oxidative stress on critical cellular processes involved in age-related macular degeneration pathobiology. We also offer targeted therapy that may define how antioxidant therapy can either prevent or improve specific stages of age-related macular degeneration. (c) 2020 Elsevier Inc. All rights reserved.

引用

页码：423 / 440

页数：18

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