The Effect of Interleukin 38 on Inflammation-induced Corneal Neovascularization

被引：9
作者：
Zhu, Jiangli [1 ]
Zhang, Jing [2 ]
Wang, Yan [3 ]
Chen, Jianping [2 ]
Li, Xiaopeng [1 ]
Liu, Xiangling [1 ]
Kong, Eryan [4 ]
Su, Shao B. [1 ,2 ]
Zhang, Zhongjian [4 ]
机构：
[1] Xinxiang Med Univ, Affiliated Hosp 3, Xinxiang 453000, Henan, Peoples R China
[2] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China
[3] Guangdong Inst Sci & Tech Informat & Dev Strategy, Guangdong Sci & Technol Lib, Guangzhou, Guangdong, Peoples R China
[4] Xinxiang Med Univ, Inst Psychiat & Neurosci, Xinxiang 453000, Henan, Peoples R China
来源：
CURRENT MOLECULAR MEDICINE | 2019年 / 19卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Angiogenesis; cytokine; interleukin; inflammation; IL-38; neovascularization; GENE-COMPLEX MEMBERS; ANKYLOSING-SPONDYLITIS; IN-VITRO; ANGIOGENESIS; ASSOCIATION; MECHANISMS; CLUSTER; IL-1; IDENTIFICATION; INHIBITION;
D O I：
10.2174/1566524019666190627122655
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background: Angiogenesis is tightly linked to inflammation. Cytokines of interleukin 1 (IL-1) family are key mediators in modulating inflammatory responses. Methods: In this study, we examined the role of IL-38, a member of the IL-1 family, in mediating inflammation-induced angiogenesis. Results: The results showed that the angiogenesis was attenuated by topical administration of IL-38 to the injured corneas in a mouse model of alkali-induced corneal neovascularization (CNV). Further study showed that the expression of inflammatory cytokines TNF-alpha, IL-6, IL-8 and IL-1 beta was decreased in the IL-38-treated corneas. Moreover, the angiogenic activities including the proliferation, migration and tube formation of human retinal endothelial cells were reduced by IL-38 treatment in vitro. Conclusion: The data indicate that IL-38 modulates inflammation-induced angiogenesis.
引用
收藏
页码：589 / 596
页数：8
相关论文
共 45 条
  • [1] Mechanism for IL-1β-mediated neovascularization unmasked by IL-1β knock-out mice
    Amano, K
    Okigaki, M
    Adachi, Y
    Fujiyama, S
    Mori, Y
    Kosaki, A
    Iwasaka, T
    Matsubara, H
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2004, 36 (04) : 469 - 480
  • [2] Regulation and function of interleukin-36 cytokines
    Bassoy, Esen Yonca
    Towne, Jennifer E.
    Gabay, Cem
    [J]. IMMUNOLOGICAL REVIEWS, 2018, 281 (01) : 169 - 178
  • [3] Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14
    Bensen, JT
    Dawson, PA
    Mychaleckyj, JC
    Bowden, DW
    [J]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2001, 21 (11) : 899 - 904
  • [4] Early events in HSV keratitis - setting the stage for a blinding disease
    Biswas, PS
    Rouse, BT
    [J]. MICROBES AND INFECTION, 2005, 7 (04) : 799 - 810
  • [5] Molecular mechanisms and clinical applications of angiogenesis
    Carmeliet, Peter
    Jain, Rakesh K.
    [J]. NATURE, 2011, 473 (7347) : 298 - 307
  • [6] Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production
    Choi, Yeon-Sook
    Choi, Hyun-Jung
    Min, Jeong-Ki
    Pyun, Bo-Jeong
    Maeng, Yong-Sun
    Park, Hongryeol
    Kim, Jihye
    Kim, Young-Myeong
    Kwon, Young-Guen
    [J]. BLOOD, 2009, 114 (14) : 3117 - 3126
  • [7] Replication of association of IL1 gene complex members with ankylosing spondylitis in Taiwanese Chinese
    Chou, C. -T.
    Timms, A. E.
    Wei, J. C. C.
    Tsai, W. C.
    Wordsworth, B. P.
    Brown, M. A.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 (08) : 1106 - 1109
  • [8] Developmental and Pathological Angiogenesis
    Chung, Alicia S.
    Ferrara, Napoleone
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27, 2011, 27 : 563 - 584
  • [9] Interleukin-36 axis is modulated in patients with primary Sjogren's syndrome
    Ciccia, F.
    Accardo-Palumbo, A.
    Alessandro, R.
    Alessandri, C.
    Priori, R.
    Guggino, G.
    Raimondo, S.
    Carubbi, F.
    Valesini, G.
    Giacomelli, R.
    Rizzo, A.
    Triolo, G.
    [J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2015, 181 (02) : 230 - 238
  • [10] Inhibition of interleukin-1 but not tumor necrosis factor suppresses neovascularization in rat models of corneal angiogenesis and adjuvant arthritis
    Coxon, A
    Bolon, B
    Estrada, J
    Kaufman, S
    Scully, S
    Rattan, A
    Duryea, D
    Hu, YL
    Rex, K
    Pacheco, E
    Van, G
    Zack, D
    Feige, U
    [J]. ARTHRITIS AND RHEUMATISM, 2002, 46 (10): : 2604 - 2612
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