Effects of Cystatin C on Cognitive Impairment in Older Chinese Adults

被引：15
作者：
Cui, Zhizhen [1 ]
Cao, Guizhen [1 ]
Wang, Youyi [1 ]
Ma, Qinghua [2 ]
Wang, Congju [3 ]
Xu, Yong [1 ]
Sun, Hongpeng [1 ]
Ma, Yana [1 ]
机构：
[1] Soochow Univ, Sch Publ Hlth, Dept Child Hlth, Jiangsu Key Lab Prevent & Translat Med Geriatr Di, Suzhou 215123, Peoples R China
[2] 3rd Peoples Hosp Xiangcheng Dist, Suzhou, Peoples R China
[3] Ctr Dis Control & Prevent Suzhou Hightech Zone, Suzhou, Peoples R China
来源：
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS | 2020年 / 35卷
基金：
中国国家自然科学基金;
关键词：
cystatin C; cognitive impairment; longitudinal studies; decision tree; logistic regression models;
D O I：
10.1177/1533317520965101
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Objective: To find a suitable dividing value to classify cystatin C and evaluate the association between cognition and levels of cystatin C. Methods: Using data from the China Health and Retirement Longitudinal Study, We conducted a longitudinal analysis of a prospective cohort of 6,869 middle-aged and older Chinese without cognitive impairment at baseline. Levels of cystatin C were categorized into 2 groups by method of decision tree. Logistic regression models evaluated whether cystatin C was related to cognitive impairment. Results: Respondents were categorized as lower levels of cystatin C and higher levels of cystatin C, cut-point was 1.11 mg/L. Higher levels of cystatin C was associated with the odds of cognitive impairment (OR, 1.56; 95% CI, 1.10-2.22) after multivariable adjustment. Respondents with higher levels of cystatin C had worse cognition scores. Conclusions: We found a suitable dividing value of cystatin C in middle-aged and older Chinese.
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页数：6
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