Rapid volumetric angiography of cortical microvasculature with optical coherence tomography

被引：134

作者：

Srinivasan, Vivek J. ^{[1
]}

Jiang, James Y. ^{[2
]}

Yaseen, Mohammed A. ^{[1
]}

Radhakrishnan, Harsha ^{[1
]}

Wu, Weicheng ^{[1
]}

Barry, Scott ^{[2
]}

Cable, Alex E. ^{[2
]}

Boas, David A. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp,Photon Migrat Imaging Lab, Athinoula A Martinos Ctr Biomed Imaging,MIT, Charlestown, MA 02129 USA

[2] Thorlabs Inc, Newton, NJ 07860 USA

来源：

OPTICS LETTERS | 2010年 / 35卷 / 01期

基金：

美国国家卫生研究院;

关键词：

CCD imaging - Hypercapnia - Micro-vasculature - Vasculature - Volumetric Imaging;

D O I：

10.1364/OL.35.000043

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We describe methods and algorithms for rapid volumetric imaging of cortical vasculature with optical coherence tomography (OCT). By optimizing system design, scanning protocols, and algorithms for visualization of capillary flow, comprehensive imaging of the surface pial vasculature and capillary bed is performed in approximately 12 s. By imaging during hypercapnia and comparing with simultaneous CCD imaging, the sources of contrast of OCT angiography are investigated. (C) 2009 Optical Society of America

引用

页码：43 / 45

页数：3

共 9 条

[1] Mobility and transverse flow visualization using phase variance contrast with spectral domain optical coherence tomography [J].

Fingler, Jeff ;

Schwartz, Dan ;

Yang, Changhuei ;

Fraser, Scott E. .

OPTICS EXPRESS, 2007, 15 (20) :12636-12653

[2] Spatial flow-volume dissociation of the cerebral microcirculatory response to mild hypercapnia [J].

Hutchinson, Elizabeth B. ;

Stefanovic, Bojana ;

Koretsky, Alan P. ;

Silva, Afonso C. .

NEUROIMAGE, 2006, 32 (02) :520-530

[3] Speckle variance detection of microvasculature using swept-source optical coherence tomography [J].

Mariampillai, Adrian ;

Standish, Beau A. ;

Moriyama, Eduardo H. ;

Khurana, Mamta ;

Munce, Nigel R. ;

Leung, Michael K. K. ;

Jiang, James ;

Cable, Alex ;

Wilson, Brian C. ;

Vitkin, I. Alex ;

Yang, Victor X. D. .

OPTICS LETTERS, 2008, 33 (13) :1530-1532

[4] T-matrix computations of light scattering by red blood cells [J].

Nilsson, AMK ;

Alsholm, P ;

Karlsson, A ;

Andersson-Engels, S .

APPLIED OPTICS, 1998, 37 (13) :2735-2748

[5] FLUID DROP-LIKE TRANSITION OF ERYTHROCYTES UNDER SHEAR [J].

SCHMIDSCHONBEIN, H ;

WELLS, R .

SCIENCE, 1969, 165 (3890) :288-+

[6] Single-pass volumetric bidirectional blood flow imaging spectral domain optical coherence tomography using a modified Hilbert transform [J].

Tao, Yuankai K. ;

Davis, Anjul M. ;

Izatt, Joseph A. .

OPTICS EXPRESS, 2008, 16 (16) :12350-12361

[7] Statistical Properties of Phase-Decorrelation in Phase-Resolved Doppler Optical Coherence Tomography [J].

Vakoc, Benjamin J. ;

Tearney, Guillermo J. ;

Bouma, Brett E. .

IEEE TRANSACTIONS ON MEDICAL IMAGING, 2009, 28 (06) :814-821

[8] Three dimensional optical angiography [J].

Wang, Ruikang K. ;

Jacques, Steven L. ;

Ma, Zhenhe ;

Hurst, Sawan ;

Hanson, Stephen R. ;

Gruber, Andras .

OPTICS EXPRESS, 2007, 15 (07) :4083-4097

[9] Doppler optical micro-angiography for volumetric imaging of vascular perfusion in vivo [J].

Wang, Ruikang K. ;

An, Lin .

OPTICS EXPRESS, 2009, 17 (11) :8926-8940

← 1 →