The study of drug permeation through natural membranes

被引:37
作者
Ansari, Mehdi [1 ]
Kazemipour, Maryam
Aklamli, Monireh
机构
[1] Kerman Med Sci Univ, Fac Pharm, Dept Pharmaceut, Kerman, Iran
[2] Kerman Med Sci Univ, Fac Sci, Dept Chem, Kerman, Iran
关键词
drug; permeation; natural; membrane; diffusion;
D O I
10.1016/j.ijpharm.2006.07.034
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In this study, natural membranes such as the outer membrane of Prunus persica (peach) and Lycopersicon esculentum (tomato), the inner layer of the egg of Gallus domesticus (hen) and the middle membrane of the Allium cepa (onion) were used as controlling barriers for permeation of some model drugs with different MW and lipophilicities. Drug permeation studies were done by using modified Franz diffusion cell. The permeation of drugs through these natural membranes was compared to permeation of them through human skin and synthetic cellophane membrane. Results showed that the rate and amount of diclofenac permeated through onion membrane was not significantly different from that with tomato (p > 0.17), egg (p > 0.29) and human skin (p > 0.93). Permeation of diclofenac through tomato skin and cellophane was not significantly different (P > 0.35). Permeation of diclofenac through all studied membranes except for human skin that follows the Fickian kinetic followed non-Fickian mechanism and their permeabilities were not significantly different from each other (p > 0.05). Permeation of metronidazole through onion membrane and tomato skin were not significantly different from human skin (p > 0.053 and 0.38, respectively). All membranes were significantly different from each other (p < 0.0001) for permeation of erythromycin as a relatively large molecular weight and lipohilic molecule through human skin and other studied membranes. Permeation of diclofenae through human skin and metronidazole through egg and tomato skin followed Fick's first law. Diffusion of diclofenac through onion, tomato, egg, cellophane, and peach; metronidazole through onion, peach, cellophane, and human skin, and erythromycin through all studied membranes followed non-Fickian mechanism for diffusion. Statistical analysis showed the most similarity between onion and human skin for diclofenac, tomato and human skin for metronidazole, onion and cellophane for erythromycin. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:6 / 11
页数:6
相关论文
共 21 条
[1]   Relationships between structure and high-throughput screening permeability of peptide derivatives and related compounds with artificial membranes: application to prediction of Caco-2 cell permeability [J].
Ano, R ;
Kimura, Y ;
Shima, M ;
Matsuno, R ;
Ueno, T ;
Akamatsu, M .
BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (01) :257-264
[2]   Drug delivery routes in skin: a novel approach [J].
Barry, BW .
ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 :S31-S40
[3]  
BARRY BW, 1983, DERMATOLOGICAL FORMU, P138
[4]   PAMPA -: a drug absorption in vitro model 7.: Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones [J].
Bermejo, M ;
Avdeef, A ;
Ruiz, A ;
Nalda, R ;
Ruell, JA ;
Tsinman, O ;
González, I ;
Fernández, C ;
Sánchez, G ;
Garrigues, TM ;
Merino, V .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2004, 21 (04) :429-441
[5]  
BIJ P, 2003, INT J PHARM, V261, P147
[6]   High throughput artificial membrane permeability assay for blood-brain barrier [J].
Di, L ;
Kerns, EH ;
Fan, K ;
McConnell, OJ ;
Carter, GT .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2003, 38 (03) :223-232
[7]   Temperature-modulated permeation of hydroxy urea through thermotropic liquid crystals embedded in poly-HEMA [J].
Dinarvand, R ;
Ansari, M .
JOURNAL OF MEMBRANE SCIENCE, 2003, 223 (1-2) :217-226
[8]   Simulation of skin permeability in chitosan membranes [J].
Dureja, H ;
Tiwary, AK ;
Gupta, S .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2001, 213 (1-2) :193-198
[9]   PERCUTANEOUS ABSORPTION - RELEVANCE OF INVITRO DATA [J].
FRANZ, TJ .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1975, 64 (03) :190-195
[10]   Mechanism of bacitracin permeation enhancement through the skin and cellular membranes from an ethosomal carrier [J].
Godin, B ;
Touitou, E .
JOURNAL OF CONTROLLED RELEASE, 2004, 94 (2-3) :365-379