A systematic review and meta-analysis of Histoscanning™ in prostate cancer diagnostics

被引:1
作者
Morozov, Andrey [1 ]
Kozlov, Vasiliy [2 ]
Rivas, Juan Gomez [3 ]
Teoh, Jeremy Yuen-Chun [4 ]
Bezrukov, Evgeniy [1 ]
Amosov, Alexander [1 ]
Barret, Eric [5 ]
Taratkin, Mark [1 ]
Salomon, Georg [6 ]
Herrmann, Thomas R. W. [7 ,8 ]
Gozen, Ali [9 ]
Enikeev, Dmitry [1 ]
机构
[1] Sechenov Univ, Inst Urol & Reprod Hlth, Bolshaya Pirogovskaya Str 2 Bld 1, Moscow 119991, Russia
[2] Sechenov Univ, Dept Publ Hlth & Healthcare, Moscow, Russia
[3] Clin San Carlos Univ Hosp, Dept Urol, Madrid, Spain
[4] Chinese Univ Hong Kong, SH Ho Urol Ctr, Dept Surg, Hong Kong, Peoples R China
[5] Inst Mutualiste Montsouris, Dept Urol, Paris, France
[6] Univ Med Ctr Hamburg Eppendorf, Martini Clin, Hamburg, Germany
[7] Spital Thurgau AG, Dept Urol, Pfaffenholzstr 4, CH-8501 Frauenfeld, Switzerland
[8] Hannover Med Sch, Dept Urol, Hannover, Germany
[9] Heidelberg Univ, SLK Kliniken Urol Dept, Heilbronn, Germany
关键词
Systematic review; Prostate cancer; Imaging; Ultrasound; Histoscanning;
D O I
10.1007/s00345-021-03684-8
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Context The value of Histoscanning (TM) (HS) in prostate cancer (PCa) imaging is much debated, although it has been used in clinical practice for more than 10 years now. Objective To summarize the data on HS from various PCa diagnostic perspectives to determine its potential. Materials and methods We performed a systematic search using 2 databases (Medline and Scopus) on the query "Histoscan*". The primary endpoint was HS accuracy. The secondary endpoints were: correlation of lesion volume by HS and histology, ability of HS to predict extracapsular extension or seminal vesicle invasion. Results HS improved cancer detection rate "per core", OR = 16.37 (95% CI 13.2; 20.3), p < 0.0001, I-2 = 98% and "per patient", OR = 1.83 (95% CI 1.51; 2.21), p < 0.0001, I-2 = 95%. The pooled accuracy was markedly low: sensitivity - 0.2 (95% CI 0.19-0.21), specificity - 0.12 (0.11-0.13), AUC 0.12. 8 of 10 studiers showed no additional value for HS. The pooled accuracy with histology after RP was relatively better, yet still very low: sensitivity - 0.56 (95% CI 0.5-0.63), specificity - 0.23 (0.18-0.28), AUC 0.4. 9 of 12 studies did not show any benefit of HS. Conclusion This meta-analysis does not see the incremental value in comparing prostate Histoscanning with conventional TRUS in prostate cancer screening and targeted biopsy. HS proved to be slightly more accurate in predicting extracapsular extension on RP, but the available data does not allow us to draw any conclusions on its effectiveness in practice. Patient summary Histoscanning is a modification of ultrasound for prostate cancer visualization. The available data suggest its low accuracy in screening and detecting of prostate cancer.
引用
收藏
页码:3733 / 3740
页数:8
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