High-throughput screening of molecular catalysts using automated liquid handling, injection, and microdevices

被引：29

作者：

de Bellefon, C ^{[1
]}

Abdallah, R ^{[1
]}

Lamouille, T ^{[1
]}

Pestre, N ^{[1
]}

Caravieilhes, S ^{[1
]}

Grenouillet, P ^{[1
]}

机构：

[1] CNRS, ESCPE Lyon, Lab Genie Procedes Catalyt, F-69616 Villeurbanne, France

来源：

CHIMIA | 2002年 / 56卷 / 11期

关键词：

asymmetric hydrogenation; high-throughput screening; homogeneous catalysis; kinetics; microreactor;

D O I：

10.2533/000942902777680018

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new concept for the high-throughput screening of multiphase reactions involving molecular catalysts is described. It combines pulse injections of catalysts and substrate and mixing in a microdevice. The novelty of the concept resides in dynamic sequential vs. batchwise operations. Some advantages over traditional batch parallel operations are lower inventory of sample (down to mug) coupled with accurate control of reaction time, larger range of operating conditions (pressure, temperature), simpler and fewer electromechanical moving parts and easy automation. Results on liquid-liquid (biphasic allylic alcohol isomerization), and gas-liquid (asymmetric hydrogenation) reactions indicates that the number of tests per day can easily reach 50 d-(1) with inventory of sample (Rh) per test as low as 5 mug.

引用

页码：621 / 626

页数：6

共 25 条

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