Cardiac arrest in takotsubo syndrome: results from the InterTAK Registry

被引：89

作者：

Gili, Sebastiano ^{[1
,2
]}

Cammann, Victoria L. ^{[1
]}

Schlossbauer, Susanne A. ^{[1
]}

Kato, Ken ^{[1
]}

D'Ascenzo, Fabrizio ^{[2
]}

Di Vece, Davide ^{[1
]}

Jurisic, Stjepan ^{[1
]}

Micek, Jozef ^{[1
]}

Obeid, Slayman ^{[1
]}

Bacchi, Beatrice ^{[1
]}

Szawan, Konrad A. ^{[1
]}

Famos, Flurina ^{[1
]}

Sarcon, Annahita ^{[3
]}

Levinson, Rena ^{[1
,4
]}

Ding, Katharina J. ^{[1
]}

Seifert, Burkhardt ^{[5
]}

Lenoir, Olivia ^{[1
]}

Bossone, Eduardo ^{[6
]}

Citro, Rodolfo ^{[7
]}

Franke, Jennifer ^{[8
]}

Napp, L. Christian ^{[9
]}

Jaguszewski, Milosz ^{[10
]}

Noutsias, Michel ^{[11
]}

Muenzel, Thomas ^{[12
]}

Knorr, Maike ^{[12
]}

Heiner, Susanne ^{[12
]}

Katus, Hugo A. ^{[8
]}

Burgdorf, Christof ^{[13
]}

Schunkert, Heribert ^{[14
,15
]}

Thiele, Holger ^{[16
]}

Bauersachs, Johann ^{[9
]}

Tschoepe, Carsten ^{[17
]}

Pieske, Burkert M. ^{[17
]}

Rajan, Lawrence ^{[18
]}

Michels, Guido ^{[19
]}

Pfister, Roman ^{[19
]}

Cuneo, Alessandro ^{[20
]}

Jacobshagen, Claudius ^{[21
]}

Hasenfuss, Gerd ^{[22
]}

Karakas, Mahir ^{[22
,23
]}

Koenig, Wolfgang ^{[14
,15
]}

Rottbauer, Wolfgang ^{[24
]}

Said, Samir M. ^{[25
]}

Braun-Dullaeus, Ruediger C. ^{[25
]}

Banning, Adrian ^{[26
]}

Cuculi, Florim ^{[27
]}

Kobza, Richard ^{[27
]}

Fischer, Thomas A. ^{[28
]}

Vasankari, Tuija ^{[29
,30
]}

Airaksinen, K. E. Juhani ^{[29
,30
]}

机构：

[1] Univ Hosp Zurich, Univ Heart Ctr, Dept Cardiol, Zurich, Switzerland

[2] Univ Turin, Div Cardiol, Dept Med Sci, AOU Citta Salute & Sci, Turin, Italy

[3] Univ Southern Calif, Keck Sch Med, Los Angeles, CA USA

[4] Univ Calif San Diego, Div Biol Sci, San Diego, CA 92103 USA

[5] Univ Zurich, Biostat & Prevent Inst, Div Biostat Epidemiol, Zurich, Switzerland

[6] Antonio Cardarelli Hosp, Div Cardiol, Naples, Italy

[7] Univ Hosp San Giovanni di Dio & Ruggi dAragona, Heart Dept, Salerno, Italy

[8] Heidelberg Univ Hosp, Dept Cardiol, Heidelberg, Germany

[9] Hannover Med Sch, Dept Cardiol & Angiol, Hannover, Germany

[10] Med Univ Gdansk, Dept Cardiol 1, Gdansk, Poland

[11] Martin Luther Univ Halle Wittenberg, Univ Hosp Halle, Dept Internal Med Angiol & Intens Med Care 3, Div Cardiol, Halle, Saale, Germany

[12] Univ Med Ctr Mainz, Ctr Cardiol, Cardiol 1, Mainz, Germany

[13] Heart & Vasc Ctr Bad Bevensen, Bad Bevensen, Germany

[14] Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany

[15] DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany

[16] Univ Leipzig, Dept Internal Med Cardiol, Heart Ctr, Leipzig, Germany

[17] Charite, Dept Cardiol, Campus Rudolf Virchow, Berlin, Germany

[18] TJ Hlth Partners Heart & Vasc, Glasgow, KY USA

[19] Univ Cologne, Dept Internal Med 3, Heart Ctr, Cologne, Germany

[20] Krankenhaus Maria Hilf Med Klin, Stadtlohn, Germany

[21] Georg August Univ Goettingen, Clin Cardiol & Pneumol, Gottingen, Germany

[22] Univ Heart Ctr Hamburg, Dept Gen & Intervent Cardiol, Hamburg, Germany

[23] DZHK German Ctr Cardiovasc Res, Partner Site Hamburg Kiel Luebeck, Hamburg, Germany

[24] Univ Ulm, Med Ctr, Dept Internal Med Cardiol 2, Ulm, Germany

[25] Magdeburg Univ, Internal Med Cardiol Angiol & Pneumol, Magdeburg, Germany

[26] Oxford Univ Hosp, John Radcliffe Hosp, Dept Cardiol, Oxford, England

[27] Kantonsspital Lucerne, Dept Cardiol, Luzern, Switzerland

[28] Kantonsspital Winterthur, Dept Cardiol, Winterthur, Switzerland

[29] Turku Univ Hosp, Heart Ctr, Turku, Finland

[30] Univ Turku, Turku, Finland

[31] Med Univ Warsaw, Dept Cardiol, Warsaw, Poland

[32] Kings Coll Hosp London, Dept Cardiol, Kings Hlth Partners, London, England

[33] Univ Hosp Basel, Dept Cardiol, Basel, Switzerland

[34] Catholic Univ Sacred Heart Rome, Dept Cardiovasc Sci, Rome, Italy

[35] Med Univ Innsbruck, Univ Hosp Internal Med Cardiol & Angiol 3, Innsbruck, Austria

[36] Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany

[37] DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany

[38] Univ Hosp Rangueil, Dept Cardiol, Toulouse, France

[39] Univ Hosp Rangueil, Cardiac Imaging Ctr, Toulouse, France

[40] Heidelberg Univ, Dept Med 1, Fac Med, Univ Med Ctr Mannheim UMM, Mannheim, Germany

[41] DZHK German Ctr Cardiovasc Res, Partner Site, Heidelberg, Germany

[42] Moscow City Hosp 1, Intens Coronary Care Unit, Moscow, Russia

[43] Univ Adelaide, Queen Elizabeth Hosp, Discipline Med, Adelaide, SA, Australia

[44] Charles Univ Prague, Med Fac 3, Prague, Czech Republic

[45] Univ Hosp Kralovske Vinohrady, Prague, Czech Republic

[46] Univ Florida, Coll Med, Dept Med, Gainesville, FL USA

[47] Univ Klinikum Saarlandes, Klin Innere Med 3, Homburg, Germany

[48] Univ Hosp Careggi, Struct Intervent Cardiol, Florence, Italy

[49] Univ Bremen, FB Math & Comp Sci, Bremen, Germany

[50] Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands

来源：

EUROPEAN HEART JOURNAL | 2019年 / 40卷 / 26期

关键词：

Takotsubo syndrome; Broken heart syndrome; Cardiac arrest; Acute heart failure; Outcome; LIFE-THREATENING ARRHYTHMIAS; VENTRICULAR-ARRHYTHMIAS; MYOCARDIAL EDEMA; QT PROLONGATION; TAKO-TSUBO; CARDIOMYOPATHY; STRESS; HEART; MANAGEMENT; INTERVAL;

D O I：

10.1093/eurheartj/ehz170

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims We aimed to evaluate the frequency, clinical features, and prognostic implications of cardiac arrest (CA) in takotsubo syndrome (TTS). Methods and results We reviewed the records of patients with CA and known heart rhythm from the International Takotsubo Registry. The main outcomes were 60-day and 5-year mortality. In addition, predictors of mortality and predictors of CA during the acute TTS phase were assessed. Of 2098 patients, 103 patients with CA and known heart rhythm during CA were included. Compared with patients without CA, CA patients were more likely to be younger, male, and have apical TTS, atrial fibrillation (AF), neurologic comorbidities, physical triggers, and longer corrected QT-interval and lower left ventricular ejection fraction on admission. In all, 57.1% of patients with CA at admission had ventricular fibrillation/tachycardia, while 73.7% of patients with CA in the acute phase had asystole/pulseless electrical activity. Patients with CA showed higher 60-day (40.3% vs. 4.0%, P < 0.001) and 5-year mortality (68.9% vs. 16.7%, P < 0.001) than patients without CA. T-wave inversion and intracranial haemorrhage were independently associated with higher 60-day mortality after CA, whereas female gender was associated with lower 60-day mortality. In the acute phase, CA occurred less frequently in females and more frequently in patients with AF, ST-segment elevation, and higher C-reactive protein on admission. Conclusions Cardiac arrest is relatively frequent in TTS and is associated with higher short- and long-term mortality. Clinical and electrocardiographic parameters independently predicted mortality after CA.

引用

页码：2142 / 2151

页数：10

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