Congenital acute lymphoblastic leukemia: a two-case report and a review of the literature

被引：12
|
作者：
Bas Suarez, Ma Pilar [1 ]
Lopez Brito, Jezabel [2 ]
Santana Reyes, Candelaria [1 ]
Gresa Munoz, Manuel [1 ]
Diaz Pulido, Rosario [1 ]
Lodos Rojas, Jose Carlos [3 ]
机构：
[1] Univ Hosp Matern Ward Canary Isl, Dept Neonatol, Las Palmas Gran Canaria, Spain
[2] Dr Negrin Univ Hosp Grand Canary Isl, Dept Hematol, Las Palmas Gran Canaria, Spain
[3] Univ Hosp Matern Ward Canary Isl, Dept Hematol, Las Palmas Gran Canaria, Spain
来源：
EUROPEAN JOURNAL OF PEDIATRICS | 2011年 / 170卷 / 04期
关键词：
Congenital leukemia; Congenital acute lymphoblastic leukemia; Leukemia cutis; MLL gene; TRANSLOCATIONS; INFANTS; CUTIS;
D O I：
10.1007/s00431-010-1339-8
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Congenital leukemia is a rare disease with particular biological and clinical characteristics which differs from those of older children and adults. Here, we describe two cases of congenital acute lymphoblastic leukemia in two newborns with different clinical presentations (leukemia cutis vs. splenomegaly and respiratory distress) and fatal outcome. Both cases shared the expression of myeloid antigens (CD65) and cytogenetic disorders involving the MLL gene (location 11q23) which are associated to extremely poor prognosis.
引用
收藏
页码：531 / 534
页数：4
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