The usefulness of selected biomarkers in patients with valve disease

被引：21

作者：

Duchnowski, Piotr ^{[1
]}

Hryniewiecki, Tomasz ^{[1
]}

Kusmierczyk, Mariusz ^{[2
]}

Szymanski, Piotr ^{[1
]}

机构：

[1] Inst Cardiol, Dept Acquired Cardiac Defects, Warsaw, Poland

[2] Inst Cardiol, Dept Cardiosurg & Transplantol, Warsaw, Poland

来源：

BIOMARKERS IN MEDICINE | 2018年 / 12卷 / 12期

关键词：

biomarkers; EuroSCORE II; high-sensitivity C-reactive protein; postoperative complications; predictors; red blood cell count; red cell distribution width; risk stratification; valve disease; valve surgery; C-REACTIVE PROTEIN; SENSITIVITY TROPONIN-T; EUROSCORE II; CARDIOVASCULAR-DISEASE; PROGNOSTIC MARKER; OBESITY PARADOX; WEIGHT-LOSS; PERFORMANCE; INFLAMMATION; VALIDATION;

D O I：

10.2217/bmm-2018-0101

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: The aim of the study was to investigate the prognostic value of selected biomarkers in patients undergoing valve surgery. Materials & methods: A prospective study was conducted on a group of consecutive patients with hemodynamically significant valve defects that underwent elective valve repair or replacement surgery. The primary end point was anymajor adverse event including death within 30 days. Results: The study group included 416 patients. The composite end point occurred in 81 patients. At multivariate analysis high-sensitivity C-reactive protein (p = 0.03), red cell distribution width (p = 0.0001) and red blood cell count (p = 0.005) remained independent predictors of the primary end point. Conclusion: Elevated high-sensitivity C-reactive protein, red cell distribution width and red blood cell count were associated with a poorer outcome following valve surgery.

引用

页码：1341 / 1346

页数：6

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