Diabetes and pancreatic cancer: Exploring the two-way traffic

被引：53
作者：
Roy, Ayan [1 ,2 ]
Sahoo, Jayaprakash [1 ]
Kamalanathan, Sadishkumar [1 ]
Naik, Dukhabandhu [1 ]
Mohan, Pazhanivel [3 ]
Kalayarasan, Raja [4 ]
机构：
[1] Jawaharlal Inst Postgrad Med Educ & Res, Dept Endocrinol, Room 5444,4th Floor,Superspecialty Block, Pondicherry 605006, India
[2] All India Inst Med Sci, Dept Endocrinol & Metab, Jodhpur 342005, Rajasthan, India
[3] Jawaharlal Inst Postgrad Med Educ & Res, Dept Gastroenterol, Pondicherry 605006, India
[4] Jawaharlal Inst Postgrad Med Educ & Resenrch, Dept Surg Gastroenterol, Pondicherry 605006, India
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2021年 / 27卷 / 30期
关键词：
Chronic pancreatitis; Diabetes; New onset diabetes; Pancreatic adenocarcinoma; Pancreatic cancer; Type 3c diabetes; LONG-TERM SURVIVAL; ISLET AMYLOID POLYPEPTIDE; POOR GLYCEMIC CONTROL; BLOOD-GLUCOSE LEVELS; BETA-CELL FUNCTION; NEW-ONSET; INSULIN-RESISTANCE; DUCTAL ADENOCARCINOMA; ANTIDIABETIC MEDICATIONS; METFORMIN USE;
D O I：
10.3748/wjg.v27.i30.4939
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Pancreatic cancer (PC) is often associated with a poor prognosis. Long-standing diabetes mellitus is considered as an important risk factor for its development. This risk can be modified by the use of certain antidiabetic medications. On the other hand, new-onset diabetes can signal towards an underlying PC in the elderly population. Recently, several attempts have been made to develop an effective clinical tool for PC screening using a combination of history of new-onset diabetes and several other clinical and biochemical markers. On the contrary, diabetes affects the survival after treatment for PC. We describe this intimate and complex two-way relationship of diabetes and PC in this review by exploring the underlying pathogenesis.
引用
收藏
页码：4939 / 4962
页数：24
相关论文
共 199 条
[1]   Incretin-based glucose-lowering medications and the risk of acute pancreatitis and malignancies: a meta-analysis based on cardiovascular outcomes trials [J].
Abd El Aziz, Mirna ;
Cahyadi, Oscar ;
Meier, Juris J. ;
Schmidt, Wolfgang E. ;
Nauck, Michael A. .
DIABETES OBESITY & METABOLISM, 2020, 22 (04) :699-704
[2]   Prevalence of Diabetes Mellitus in Pancreatic Cancer Compared to Common Cancers [J].
Aggarwal, Gaurav ;
Kamada, Pratima ;
Chari, Suresh T. .
PANCREAS, 2013, 42 (02) :198-201
[3]   Adrenomedullin is Up-regulated in Patients With Pancreatic Cancer and Causes Insulin Resistance in β Cells and Mice [J].
Aggarwal, Gaurav ;
Ramachandran, Vijaya ;
Javeed, Naureen ;
Arumugam, Thiruvengadam ;
Dutta, Shamit ;
Klee, George G. ;
Klee, Eric W. ;
Smyrk, Thomas C. ;
Bamlet, William ;
Han, Jing Jing ;
Vittar, Natalia B. Rumie ;
De Andrade, Mariza ;
Mukhopadhyay, Debabrata ;
Petersen, Gloria M. ;
Fernandez-Zapico, Martin E. ;
Logsdon, Craig D. ;
Chari, Suresh T. .
GASTROENTEROLOGY, 2012, 143 (06) :1510-+
[4]   Mechanisms for skeletal muscle insulin resistance in patients with pancreatic ductal adenocarcinoma [J].
Agustsson, Thorhallur ;
D'souza, Melroy A. ;
Nowak, Greg ;
Isaksson, Bengt .
NUTRITION, 2011, 27 (7-8) :796-801
[5]  
Amer Diabet Assoc, 2011, DIABETES CARE, V34, pS11, DOI [10.2337/dc14-S081, 10.2337/dc13-S011, 10.2337/dc12-s064, 10.2337/dc11-S011, 10.2337/dc10-S062, 10.2337/dc13-S067, 10.2337/dc12-s011, 10.2337/dc10-S011, 10.2337/dc11-S062]
[6]   Metformin Improves Survival in Patients with Pancreatic Ductal Adenocarcinoma and Pre-Existing Diabetes: A Propensity Score Analysis [J].
Amin, S. ;
Mhango, G. ;
Lin, J. ;
Aronson, A. ;
Wisnivesky, J. ;
Boffetta, P. ;
Lucas, Aimee L. .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2016, 111 (09) :1350-1357
[7]   Diabetes, Pancreatogenic Diabetes, and Pancreatic Cancer [J].
Andersen, Dana K. ;
Korc, Murray ;
Petersen, Gloria M. ;
Eibl, Guido ;
Li, Donghui ;
Rickels, Michael R. ;
Chari, Suresh T. ;
Abbruzzese, James L. .
DIABETES, 2017, 66 (05) :1103-1110
[8]  
[Anonymous], 2020, IDF Diabetes Atlas
[9]   Can pancreatic cancer be detected by adrenomedullin in patients with new-onset diabetes? The PaCANOD cohort study protocol [J].
Antolino, Laura ;
La Rocca, Mara ;
Todde, Federico ;
Catarinozzi, Elena ;
Aurello, Paolo ;
Bollanti, Lucilla ;
Ramacciato, Giovanni ;
D'Angelo, Francesco .
TUMORI JOURNAL, 2018, 104 (04) :312-314
[10]   Incretin based drugs and the risk of pancreatic cancer: international multicentre cohort study [J].
Azoulay, Laurent ;
Filion, Kristian B. ;
Platt, Robert W. ;
Dahl, Matthew ;
Dormuth, Colin R. ;
Clemens, Kristin K. ;
Durand, Madeleine ;
Juurlink, David N. ;
Targownik, Laura E. ;
Turin, Tanvir C. ;
Paterson, J. Michael ;
Ernst, Pierre .
BMJ-BRITISH MEDICAL JOURNAL, 2016, 352
12345678910