Palladium-Catalyzed Carbo-Heterofunctionalization of Alkenes for the Synthesis of Oxindoles and Spirooxindoles

被引：186

作者：

Jaegli, Stephanie ^{[1
]}

Dufour, Jeremy ^{[1
]}

Wei, Hai-long ^{[1
]}

Piou, Tiffany ^{[1
]}

Duan, Xin-Hua ^{[1
]}

Vors, Jean-Pierre ^{[2
]}

Neuville, Luc ^{[1
]}

Zhu, Jieping ^{[1
]}

机构：

[1] CNRS, Ctr Rech Gif, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

[2] Bayer CropSci SA, F-69009 Lyon, France

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 20期

关键词：

C-H FUNCTIONALIZATION; ASYMMETRIC-SYNTHESIS; BOND FORMATION; OXIDATIVE AMINATION; ALPHA-ARYLATION; CYCLIZATION; AMINOPALLADATION; DIAMINATION; REACTIVITY; CARBOETHERIFICATION;

D O I：

10.1021/ol101778c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed oxidative carbo-heterofunctionalization of aniline derivatives involving concomitant direct C H functionalization and C X bond formation was developed By simply changing the reaction conditions (solvent and catalyst), either 3,3'-disubstituted oxindole or spirooxindole was accessible from the same starting material.

引用

页码：4498 / 4501

页数：4

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