Bunyaviruses and the Type I Interferon System

被引:50
作者
Elliott, Richard M. [2 ]
Weber, Friedemann [1 ]
机构
[1] Univ Freiburg, Dept Virol, D-79008 Freiburg, Germany
[2] Univ St Andrews, Sch Biol, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland
来源
VIRUSES-BASEL | 2009年 / 1卷 / 03期
基金
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词
bunyaviruses; interferon system; NSs proteins; RIFT-VALLEY FEVER; NONSTRUCTURAL PROTEIN NSS; HUMAN MXA PROTEIN; DOUBLE-STRANDED-RNA; LA-CROSSE VIRUS; SIN-NOMBRE HANTAVIRUS; PUNTA-TORO-VIRUS; HEMORRHAGIC-FEVER; BUNYAMWERA VIRUS; NUCLEOCAPSID PROTEIN;
D O I
10.3390/v1031003
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The family Bunyaviridae contains more than 350 viruses that are distributed throughout the world. Most members of the family are transmitted by arthopods, and several cause disease in man, domesticated animals and crop plants. Despite being recognized as an emerging threat, details of the virulence mechanisms employed by bunyaviruses are scant. In this article we summarise the information currently available on how these viruses are able to establish infection when confronted with a powerful antiviral interferon system.
引用
收藏
页码:1003 / 1021
页数:19
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