The Role of Gut Microbiota in the Progression of Parkinson?s Disease and the Mechanism of Intervention by Traditional Chinese Medicine

被引：3
作者：
Huan, Pengfei [1 ,2 ]
Wang, Li [1 ,2 ]
He, Zhuqing [1 ,2 ]
He, Jiancheng [1 ,2 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Sch Basic Med, Shanghai 201203, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Shanghai Key Lab Hlth Identificat & Assessment, Shanghai 201203, Peoples R China
来源：
NEUROPSYCHIATRIC DISEASE AND TREATMENT | 2022年 / 18卷
基金：
中国国家自然科学基金;
关键词：
Parkinson?s disease; gut microbiota; traditional Chinese medicine; pathogenesis; REGULATORY T-CELLS; GASTROINTESTINAL-TRACT; INTESTINAL BARRIER; TIGHT JUNCTION; BRAIN; MODEL; EXPRESSION; DIET; PERMEABILITY; DYSFUNCTION;
D O I：
10.2147/NDT.S367016
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Parkinson's disease (PD) is a common degenerative disease of the nervous system that seriously affects the quality of life of the patients. The pathogenesis of PD is not yet fully clear. Previous studies have confirmed that patients with PD exhibit obvious gut microbiota imbalance, while intervention of PD by regulating the gut microbiota has become an important approach to the prevention and treatment of this disease. Traditional Chinese medicine (TCM) has been shown to be safe and effective in treating PD. It has the advantages of affecting multiple targets. Studies have shown TCM can regulate gut microbiota. However, the specific mechanism of action is still unclear. Therefore, this article will mainly discuss the association of the alteration of the gut microbiota and the incidence of PD, the advantages of TCM in treating PD, and the mechanism of regulating gut microbiota by TCM to treat PD. It will clarify the target and mechanism of TCM treating PD by acting gut microbiota and provided a novel methodology for the prevention and treatment of PD.
引用
收藏
页码：1507 / 1520
页数：14
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