Externally Induced Drug Release Systems with Magnetic Nanoparticle Carriers: An Emerging Field in Nanomedicine

被引：34

作者：

Norris, Matthew D. ^{[1
,2
]}

Seidel, Katja ^{[1
,2
]}

Kirschning, Andreas ^{[1
,2
]}

机构：

[1] Leibniz Univ Hannover, Inst Organ Chem, Schneiderberg 1B, D-30167 Hannover, Germany

[2] Leibniz Univ Hannover, Biomol Wirkstoffzentrum, Schneiderberg 1B, D-30167 Hannover, Germany

来源：

ADVANCED THERAPEUTICS | 2019年 / 2卷 / 01期

关键词：

anticancer agents; drug release; iron oxide nanoparticles; nanomedicine; superparamagnetism; IRON-OXIDE NANOPARTICLES; BIOMEDICAL APPLICATIONS; TARGETED DELIVERY; IN-VITRO; DESIGN; CANCER; FUNCTIONALIZATION; NANOMATERIALS; NANOCHEMISTRY; ANSAMITOCIN;

D O I：

10.1002/adtp.201800092

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Core-shell nanoparticles that exhibit superparamagnetic properties and stability as colloidal suspensions have been widely employed for medical imaging, diagnosis, and targeted drug delivery. These materials are engineered for spatial guidance using an external magnetic field and are capable of transporting therapeutic payloads such as clinical drugs and protein structures. They can be tagged with fluorescent dyes and quantum dots as spectroscopic markers; and can generate an acute influx of heat when exposed to an alternating magnetic field. When these functions are used in combination, core-shell nanoparticles can operate in a multimodal fashion, on demand, using external and non-invasive stimuli. In this short review, selected examples of externally induced drug release systems with magnetic nanoparticle carriers are highlighted. This new and emerging field of nanomedicine has enormous potential to advance our therapeutic capabilities with a central concept of targeting, locating, and detonating diseased and cancerous tissues in vivo with precise ex vivo control.

引用

页数：12

共 81 条

[71] Emerging advances in nanomedicine with engineered gold nanostructures [J].