Imaging challenges of immunotherapy and targeted therapy in patients with brain metastases: response, progression, and pseudoprogression

被引：103
作者：
Galldiks, Norbert [1 ,2 ,3 ,4 ,5 ]
Kocher, Martin [2 ,3 ,6 ]
Ceccon, Garry [1 ,2 ]
Werner, Jan-Michael [1 ,2 ]
Brunn, Anna [2 ,7 ]
Deckert, Martina [2 ,7 ]
Pope, Whitney B. [8 ]
Soffietti, Riccardo [9 ,10 ]
Le Rhun, Emilie [11 ,12 ,13 ,14 ,15 ]
Weller, Michael [13 ,14 ,15 ]
Tonn, Joerg C. [16 ,17 ]
Fink, Gereon R. [1 ,2 ,3 ]
Langen, Karl-Josef [3 ,18 ]
机构：
[1] Univ Cologne, Fac Med, Dept Neurol, Cologne, Germany
[2] Univ Cologne, Univ Hosp Cologne, Cologne, Germany
[3] Res Ctr Juelich, Inst Neurosci & Med, Julich, Germany
[4] Univ Aachen, Ctr Integrated Oncol, Bonn, Germany
[5] Univ Aachen, Ctr Integrated Oncol, Dusseldorf, Germany
[6] Univ Cologne, Fac Med, Dept Stereotaxy & Funct Neurosurg, Cologne, Germany
[7] Univ Cologne, Fac Med, Inst Neuropathol, Cologne, Germany
[8] Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol Sci, Los Angeles, CA 90095 USA
[9] Univ Turin, Dept Neurooncol, Turin, Italy
[10] City Hlth & Sci Hosp, Turin, Italy
[11] Univ Hosp Lille, Neurooncol Gen & Stereotax Neurosurg Serv, Lille, France
[12] Oscar Lambret Ctr, Breast Canc Dept, Lille, France
[13] Univ Hosp, Dept Neurol, Zurich, Switzerland
[14] Univ Hosp, Brain Tumor Ctr, Zurich, Switzerland
[15] Univ Zurich, Zurich, Switzerland
[16] Ludwig Maximilians Univ Munchen, Dept Neurosurg, Munich, Germany
[17] German Canc Consortium, Partner Site Munich, Munich, Germany
[18] Univ Hosp Aachen, Dept Nucl Med, Aachen, Germany
来源：
NEURO-ONCOLOGY | 2020年 / 22卷 / 01期
关键词：
brain metastasis; FET PET; immune checkpoint inhibitors; lung cancer; melanoma; radiomics; AMINO-ACID PET; POSITRON-EMISSION-TOMOGRAPHY; GAMMA-KNIFE RADIOSURGERY; RADIATION-INDUCED NECROSIS; IMMUNE CHECKPOINT THERAPY; STEREOTACTIC RADIOSURGERY; CEREBRAL METASTASES; PERFUSION-MRI; FDG-PET; MELANOMA PATIENTS;
D O I：
10.1093/neuonc/noz147
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The advent of immunotherapy using immune checkpoint inhibitors (ICIs) and targeted therapy (TT) has dramatically improved the prognosis of various cancer types. However, following ICI therapy or TT-either alone (especially ICI) or in combination with radiotherapy-imaging findings on anatomical contrast-enhanced MRI can be unpredictable and highly variable, and are often difficult to interpret regarding treatment response and outcome. This review aims at summarizing the imaging challenges related to TT and ICI monotherapy as well as combined with radiotherapy in patients with brain metastases, and to give an overview on advanced imaging techniques which potentially overcome some of these imaging challenges. Currently, major evidence suggests that imaging parameters especially derived from amino acid PET, perfusion-/diffusion-weighted MRI, or MR spectroscopy may provide valuable additional information for the differentiation of treatment-induced changes from brain metastases recurrence and the evaluation of treatment response.
引用
收藏
页码：17 / 30
页数：14
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