Functional roles of lncRNA-TUG1 in hepatocellular carcinoma

被引：32

作者：

Farzaneh, Maryam ^{[1
]}

Ghasemian, Majid ^{[2
]}

Ghaedrahmati, Farhoodeh ^{[3
]}

Poodineh, Jafar ^{[4
]}

Najafi, Sajad ^{[5
]}

Masoodi, Tariq ^{[6
]}

Kurniawan, Dedy ^{[7
]}

Uddin, Shahab ^{[8
,9
]}

Azizidoost, Shirin ^{[10
]}

机构：

[1] Ahvaz Jundishapur Univ Med Sci, Fertil Infertil & Perinatol Res Ctr, Ahvaz, Iran

[2] Shahid Beheshti Univ Med Sci, Sch Med, Dept Clin Biochem, Tehran, Iran

[3] Isfahan Univ Med Sci, Sch Med, Dept Immunol, Esfahan, Iran

[4] Zabol Univ Med Sci, Sch Med, Dept Clin Biochem, Zabol, Iran

[5] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Med Biotechnol, Tehran, Iran

[6] Canc Res Dept, Sidra Med, Doha 26999, Qatar

[7] Lab Anim & Stem Cells, PT Bio Farma Persero, Bandung 40161, West Java, Indonesia

[8] Hamad Med Corp, Translat Res Inst, Acad Hlth Syst, Doha, Qatar

[9] Hamad Med Corp, Dermatol Inst, Acad Hlth Syst, Doha, Qatar

[10] Ahvaz Jundishapur Univ Med Sci, Atherosclerosis Res Ctr, Ahvaz, Iran

来源：

LIFE SCIENCES | 2022年 / 308卷

关键词：

Hepatocellular carcinoma; LncRNAs; TUG1; Pathogenesis; NONCODING RNA TUG1; REGULATED GENE-1 PROMOTES; CANCER CELL-PROLIFERATION; MESENCHYMAL TRANSITION; CISPLATIN-RESISTANCE; COLORECTAL-CANCER; UP-REGULATION; TUMOR-GROWTH; MIGRATION; EXPRESSION;

D O I：

10.1016/j.lfs.2022.120974

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Hepatocellular carcinoma (HCC) or hepatoma is malignant cancer that starts from the main liver cells. Although various classical methods have been used for patients with HCC, various molecular mechanisms involved in HCC progression should be invested. Previous studies demonstrated that abnormal expression of long non-coding RNAs (lncRNAs) presented important roles in the pathogenesis of HCC cells. LncRNA TUG1 was found to mediate HCC cell growth, EMT, and metastasis. Therefore, targeting TUG1 and its downstream genes may be a suitable approach for patients with HCC. In this review, we summarized the potential roles of TUG1 in HCC.

引用

页数：10

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