CAR T-cell therapy in diffuse large B-cell lymphoma

被引：3

作者：

Hopfinger, Georg ^{[1
]}

Worel, Nina ^{[2
]}

机构：

[1] Med Univ Vienna, Dept Internal Med 1, Bone Marrow Transplantat Unit, Waehringer Guertel 18-20, A-1090 Vienna, Austria

[2] Med Univ Vienna, Dept Blood Grp Serol & Transfus Med, Vienna, Austria

来源：

MEMO-MAGAZINE OF EUROPEAN MEDICAL ONCOLOGY | 2020年 / 13卷 / 01期

关键词：

Tisagenlecleucel; Axicabtagene ciloleucel; Cytokine Release Syndrome; Autologous chimeric antigen receptor T-cells; Diffuse large B-cell lymphoma; TRANSPLANTATION; BLOOD; CD19;

D O I：

10.1007/s12254-019-00558-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Diffuse large B-cell lymphoma (DLBCL) comprises 30-40% of non-Hodgkin's lymphoma. Clinical factors such as a high International Prognostic Index (IPI) or molecular factors as cell of origin (COO) have an influence on the clinical outcome after conventional immunochemotherapy. Patients with resistant or relapsed (r/r) DLBCL have a poor prognosis with a median overall survival of 6,3 months and low complete response rates (CR 7%) to salvage chemoimmunotherapy. Currently, therapy with autologous chimeric antigen receptor T-cells (CAR T-cells) provide encouraging complete responses (CR) of up to 50%. However, high costs for approved products and elaborate logistics have to be encountered.

引用

页码：32 / 35

页数：4

共 22 条

[1]

Abramson JS, 2019, J CLIN ONCOL, V37

[2] Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition [J].

Cherkassky, Leonid ;

Morello, Aurore ;

Villena-Vargas, Jonathan ;

Feng, Yang ;

Dimitrov, Dimiter S. ;

Jones, David R. ;

Sadelain, Michel ;

Adusumilli, Prasad S. .

JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (08) :3130-3144

[3] Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d'Etudes des Lymphomes de l'Adulte [J].

Coiffier, Bertrand ;

Thieblemont, Catherine ;

Van Den Neste, Eric ;

Lepeu, Gerard ;

Plantier, Isabelle ;

Castaigne, Sylvie ;

Lefort, Sophie ;

Marit, Gerald ;

Macro, Margaret ;

Sebban, Catherine ;

Belhadj, Karim ;

Bordessoule, Dominique ;

Ferme, Christophe ;

Tilly, Herve .

BLOOD, 2010, 116 (12) :2040-2045

[4]

DIBLASI R, 2019, HEMASPHERE, V3, P759, DOI DOI 10.1097/01.HS9.0000564812.01649.69

[5] CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy [J].

Fry, Terry J. ;

Shah, Nirali N. ;

Orentas, Rimas J. ;

Stetler-Stevenson, Maryalice ;

Yuan, Constance M. ;

Ramakrishna, Sneha ;

Wolters, Pamela ;

Martin, Staci ;

Delbrook, Cindy ;

Yates, Bonnie ;

Shalabi, Haneen ;

Fountaine, Thomas J. ;

Shern, Jack F. ;

Majzner, Robbie G. ;

Stroncek, David F. ;

Sabatino, Marianna ;

Feng, Yang ;

Dimitrov, Dimiter S. ;

Zhang, Ling ;

Sang Nguyen ;

Qin, Haiying ;

Dropulic, Boro ;

Lee, Daniel W. ;

Mackall, Crystal L. .

NATURE MEDICINE, 2018, 24 (01) :20-+

[6] Salvage Regimens With Autologous Transplantation for Relapsed Large B-Cell Lymphoma in the Rituximab Era [J].

Gisselbrecht, Christian ;

Glass, Bertram ;

Mounier, Nicolas ;

Gill, Devinder Singh ;

Linch, David C. ;

Trneny, Marek ;

Bosly, Andre ;

Ketterer, Nicolas ;

Shpilberg, Ofer ;

Hagberg, Hans ;

Ma, David ;

Briere, Josette ;

Moskowitz, Craig H. ;

Schmitz, Norbert .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (27) :4184-4190

[7] Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells [J].

Gust, Juliane ;

Hay, Kevin A. ;

Hanafi, Laila-Aicha ;

Li, Daniel ;

Myerson, David ;

Gonzalez-Cuyar, Luis F. ;

Yeung, Cecilia ;

Liles, W. Conrad ;

Wurfel, Mark ;

Lopez, Jose A. ;

Chen, Junmei ;

Chung, Dominic ;

Harju-Baker, Susanna ;

Tzpolat, Tahsin ;

Fink, Kathleen R. ;

Riddell, Stanley R. ;

Maloney, David G. ;

Turtle, Cameron J. .

CANCER DISCOVERY, 2017, 7 (12) :1404-1419

[8]

JACOBSON CA, 2018, BLOOD, V132

[9]

Jacobson CA, 2018, BLOOD S1, V132

[10] ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells [J].

Lee, Daniel W. ;

Santomasso, Bianca D. ;

Locke, Frederick L. ;

Ghobadi, Armin ;

Turtle, Cameron J. ;

Brudno, Jennifer N. ;

Maus, Marcela, V ;

Park, Jae H. ;

Mead, Elena ;

Pavletic, Steven ;

Go, William Y. ;

Eldjerou, Lamis ;

Gardner, Rebecca A. ;

Frey, Noelle ;

Curran, Kevin J. ;

Peggs, Karl ;

Pasquini, Marcelo ;

DiPersio, John F. ;

van den Brink, Marcel R. M. ;

Komanduri, Krishna, V ;

Grupp, Stephan A. ;

Neelapu, Sattva S. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2019, 25 (04) :625-638

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