Birthweight determines intestinal microvasculature development and alters endothelial nitric oxide synthase density in young piglets
被引:2
作者:
Ayuso, Miriam
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机构:
Univ Antwerp, Fac Biomed Pharmaceut & Vet Sci, Dept Vet Sci, Lab Appl Vet Morphol, Antwerp, BelgiumUniv Antwerp, Fac Biomed Pharmaceut & Vet Sci, Dept Vet Sci, Lab Appl Vet Morphol, Antwerp, Belgium
Ayuso, Miriam
[1
]
Van Cruchten, Steven
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机构:
Univ Antwerp, Fac Biomed Pharmaceut & Vet Sci, Dept Vet Sci, Lab Appl Vet Morphol, Antwerp, BelgiumUniv Antwerp, Fac Biomed Pharmaceut & Vet Sci, Dept Vet Sci, Lab Appl Vet Morphol, Antwerp, Belgium
Van Cruchten, Steven
[1
]
Van Ginneken, Chris
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h-index: 0
机构:
Univ Antwerp, Fac Biomed Pharmaceut & Vet Sci, Dept Vet Sci, Lab Appl Vet Morphol, Antwerp, BelgiumUniv Antwerp, Fac Biomed Pharmaceut & Vet Sci, Dept Vet Sci, Lab Appl Vet Morphol, Antwerp, Belgium
Van Ginneken, Chris
[1
]
机构:
[1] Univ Antwerp, Fac Biomed Pharmaceut & Vet Sci, Dept Vet Sci, Lab Appl Vet Morphol, Antwerp, Belgium
Blood supply to enterocytes dictates intestinal health and nutrient absorption. These two aspects are impaired in low birthweight (LBW) piglets, but whether the perfusion to intestinal tissues is implicated as well is still unknown. Thus, structural changes in the microvasculature of LBW and normal birthweight (NBW) piglets were investigated during early postnatal development. Additionally, the presence of endothelial nitric oxide synthase (eNOS) in the intestinal mucosa was assessed given its important role to assure perfusion. A total of 22 pigs (11 LBW and 11 NBW) were sacrificed at days 0, 3, 8 and 19 of life. Body weight and intestinal length were recorded and a piece of the small intestine was sampled for immunohistochemical analysis of von Willebrand Factor (vWF, an endothelial cell marker) and eNOS. LBW piglets had a relatively (to body weight) longer intestine than their NBW counterparts. Age did not affect microvasculature, which was more abundant (85% larger vWF-positive area) in NBW than LBW pigs. However, an interaction age*BW was observed for eNOS-IR, showing that eNOS presence peaked in NBW piglets on the first day of life and subsequently decreased. This pattern was not observed in LBW piglets. The less abundant intestinal endothelial mass and the different pattern of eNOS expression observed in LBW piglets suggests microcirculation as a contributing factor in the impaired digestive functioning and gut health of LBW pigs. However, revealing whether the origin of this alteration is prenatal or postnatal, for example due to a lower milk intake, needs further study.
机构:
Rush Univ, Med Ctr, Dept Pediat, Sect Neonatol, Chicago, IL 60612 USARush Univ, Med Ctr, Dept Pediat, Sect Neonatol, Chicago, IL 60612 USA
Bowker, Rakhee M.
;
Yan, Xiaocai
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Div Neonatol,Feinberg Sch Med, Chicago, IL 60611 USARush Univ, Med Ctr, Dept Pediat, Sect Neonatol, Chicago, IL 60612 USA
Yan, Xiaocai
;
De Plaen, Isabelle G.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Div Neonatol,Feinberg Sch Med, Chicago, IL 60611 USA
Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Stanley Manne Childrens Res Inst, Ctr Intestinal & Liver Inflammat Res, Chicago, IL 60611 USARush Univ, Med Ctr, Dept Pediat, Sect Neonatol, Chicago, IL 60612 USA
机构:
Northwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Stanley Manne Childrens Res Inst, Ctr Intestinal & Liver Inflammat Res, Chicago, IL 60611 USANorthwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Bowker, Rakhee M.
;
Yan, Xiaocai
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Stanley Manne Childrens Res Inst, Ctr Intestinal & Liver Inflammat Res, Chicago, IL 60611 USANorthwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Yan, Xiaocai
;
Managlia, Elizabeth
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Stanley Manne Childrens Res Inst, Ctr Intestinal & Liver Inflammat Res, Chicago, IL 60611 USANorthwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Managlia, Elizabeth
;
Liu, Shirley X. L.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Stanley Manne Childrens Res Inst, Ctr Intestinal & Liver Inflammat Res, Chicago, IL 60611 USANorthwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Liu, Shirley X. L.
;
Marek, Catherine
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Stanley Manne Childrens Res Inst, Ctr Intestinal & Liver Inflammat Res, Chicago, IL 60611 USANorthwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Marek, Catherine
;
Tan, Xiao-Di
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Stanley Manne Childrens Res Inst, Ctr Intestinal & Liver Inflammat Res, Chicago, IL 60611 USA
Northwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Gastroenterol, Chicago, IL 60611 USANorthwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Tan, Xiao-Di
;
De Plaen, Isabelle G.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Stanley Manne Childrens Res Inst, Ctr Intestinal & Liver Inflammat Res, Chicago, IL 60611 USANorthwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
机构:
Sichuan Agr Univ, Inst Anim Nutr, Chengdu 625014, Sichuan, Peoples R ChinaUniv Copenhagen, Dept Human Nutr, Fac Life Sci, DK-1958 Copenhagen, Denmark
Che, Lianqiang
;
Thymann, Thomas
论文数: 0引用数: 0
h-index: 0
机构:Univ Copenhagen, Dept Human Nutr, Fac Life Sci, DK-1958 Copenhagen, Denmark
Thymann, Thomas
;
Bering, Stine B.
论文数: 0引用数: 0
h-index: 0
机构:Univ Copenhagen, Dept Human Nutr, Fac Life Sci, DK-1958 Copenhagen, Denmark
Bering, Stine B.
;
Le Huerou-Luron, Isabelle
论文数: 0引用数: 0
h-index: 0
机构:
SENAH, UMR 1079, INRA, F-35590 St Gilles, France
Agrocampus Ouest, UMR 1079, SENAH, F-35000 Rennes, FranceUniv Copenhagen, Dept Human Nutr, Fac Life Sci, DK-1958 Copenhagen, Denmark
Le Huerou-Luron, Isabelle
;
D'Inca, Romain
论文数: 0引用数: 0
h-index: 0
机构:
SENAH, UMR 1079, INRA, F-35590 St Gilles, France
Agrocampus Ouest, UMR 1079, SENAH, F-35000 Rennes, FranceUniv Copenhagen, Dept Human Nutr, Fac Life Sci, DK-1958 Copenhagen, Denmark
D'Inca, Romain
;
Zhang, Keying
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Agr Univ, Inst Anim Nutr, Chengdu 625014, Sichuan, Peoples R ChinaUniv Copenhagen, Dept Human Nutr, Fac Life Sci, DK-1958 Copenhagen, Denmark
Zhang, Keying
;
Sangild, Per T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Copenhagen, Dept Human Nutr, Fac Life Sci, DK-1958 Copenhagen, DenmarkUniv Copenhagen, Dept Human Nutr, Fac Life Sci, DK-1958 Copenhagen, Denmark
机构:
Univ Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA
Chin, Alana M.
;
Hill, David R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA
Hill, David R.
;
Aurora, Megan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Pediat, Div Neonatal Perinatal Med, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA
Aurora, Megan
;
Spence, Jason R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Ctr Organogenesis, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA
机构:
Rush Univ, Med Ctr, Dept Pediat, Sect Neonatol, Chicago, IL 60612 USARush Univ, Med Ctr, Dept Pediat, Sect Neonatol, Chicago, IL 60612 USA
Bowker, Rakhee M.
;
Yan, Xiaocai
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Div Neonatol,Feinberg Sch Med, Chicago, IL 60611 USARush Univ, Med Ctr, Dept Pediat, Sect Neonatol, Chicago, IL 60612 USA
Yan, Xiaocai
;
De Plaen, Isabelle G.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Div Neonatol,Feinberg Sch Med, Chicago, IL 60611 USA
Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Stanley Manne Childrens Res Inst, Ctr Intestinal & Liver Inflammat Res, Chicago, IL 60611 USARush Univ, Med Ctr, Dept Pediat, Sect Neonatol, Chicago, IL 60612 USA
机构:
Northwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Stanley Manne Childrens Res Inst, Ctr Intestinal & Liver Inflammat Res, Chicago, IL 60611 USANorthwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Bowker, Rakhee M.
;
Yan, Xiaocai
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Stanley Manne Childrens Res Inst, Ctr Intestinal & Liver Inflammat Res, Chicago, IL 60611 USANorthwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Yan, Xiaocai
;
Managlia, Elizabeth
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Stanley Manne Childrens Res Inst, Ctr Intestinal & Liver Inflammat Res, Chicago, IL 60611 USANorthwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Managlia, Elizabeth
;
Liu, Shirley X. L.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Stanley Manne Childrens Res Inst, Ctr Intestinal & Liver Inflammat Res, Chicago, IL 60611 USANorthwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Liu, Shirley X. L.
;
Marek, Catherine
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Stanley Manne Childrens Res Inst, Ctr Intestinal & Liver Inflammat Res, Chicago, IL 60611 USANorthwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Marek, Catherine
;
Tan, Xiao-Di
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Stanley Manne Childrens Res Inst, Ctr Intestinal & Liver Inflammat Res, Chicago, IL 60611 USA
Northwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Gastroenterol, Chicago, IL 60611 USANorthwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Tan, Xiao-Di
;
De Plaen, Isabelle G.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Stanley Manne Childrens Res Inst, Ctr Intestinal & Liver Inflammat Res, Chicago, IL 60611 USANorthwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med,Div Neonatol, Chicago, IL 60611 USA
机构:
Sichuan Agr Univ, Inst Anim Nutr, Chengdu 625014, Sichuan, Peoples R ChinaUniv Copenhagen, Dept Human Nutr, Fac Life Sci, DK-1958 Copenhagen, Denmark
Che, Lianqiang
;
Thymann, Thomas
论文数: 0引用数: 0
h-index: 0
机构:Univ Copenhagen, Dept Human Nutr, Fac Life Sci, DK-1958 Copenhagen, Denmark
Thymann, Thomas
;
Bering, Stine B.
论文数: 0引用数: 0
h-index: 0
机构:Univ Copenhagen, Dept Human Nutr, Fac Life Sci, DK-1958 Copenhagen, Denmark
Bering, Stine B.
;
Le Huerou-Luron, Isabelle
论文数: 0引用数: 0
h-index: 0
机构:
SENAH, UMR 1079, INRA, F-35590 St Gilles, France
Agrocampus Ouest, UMR 1079, SENAH, F-35000 Rennes, FranceUniv Copenhagen, Dept Human Nutr, Fac Life Sci, DK-1958 Copenhagen, Denmark
Le Huerou-Luron, Isabelle
;
D'Inca, Romain
论文数: 0引用数: 0
h-index: 0
机构:
SENAH, UMR 1079, INRA, F-35590 St Gilles, France
Agrocampus Ouest, UMR 1079, SENAH, F-35000 Rennes, FranceUniv Copenhagen, Dept Human Nutr, Fac Life Sci, DK-1958 Copenhagen, Denmark
D'Inca, Romain
;
Zhang, Keying
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Agr Univ, Inst Anim Nutr, Chengdu 625014, Sichuan, Peoples R ChinaUniv Copenhagen, Dept Human Nutr, Fac Life Sci, DK-1958 Copenhagen, Denmark
Zhang, Keying
;
Sangild, Per T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Copenhagen, Dept Human Nutr, Fac Life Sci, DK-1958 Copenhagen, DenmarkUniv Copenhagen, Dept Human Nutr, Fac Life Sci, DK-1958 Copenhagen, Denmark
机构:
Univ Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA
Chin, Alana M.
;
Hill, David R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA
Hill, David R.
;
Aurora, Megan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Pediat, Div Neonatal Perinatal Med, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA
Aurora, Megan
;
Spence, Jason R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Ctr Organogenesis, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA