The role of non-HLA single nucleotide polymorphisms in multiple sclerosis susceptibility

被引：19

作者：

Bahreini, Seyed Amir ^{[1
]}

Jabalameli, M. Reza ^{[1
]}

Saadatnia, Mohammad ^{[2
,3
]}

Zahednasab, Hamid ^{[1
]}

机构：

[1] Univ Isfahan, Fac Sci, Dept Biol, Esfahan, Iran

[2] Isfahan Univ Med Sci, Fac Med, Dept Neurol, Esfahan, Iran

[3] Isfahan Univ Med Sci, Isfahan Neurosci Res Ctr, Esfahan, Iran

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2010年 / 229卷 / 1-2期

关键词：

Non-HLA genes; Multiple sclerosis; Genome-wide association study; Single nucleotide polymorphism; KINASE-C-ALPHA; ADHESION MOLECULE-1 GENE; GENOME-WIDE ASSOCIATION; SYSTEMIC-LUPUS-ERYTHEMATOSUS; 2 INDEPENDENT POPULATIONS; INTERFERON-GAMMA GENE; INTERLEUKIN-7; RECEPTOR; RHEUMATOID-ARTHRITIS; NITRIC-OXIDE; CONFER SUSCEPTIBILITY;

D O I：

10.1016/j.jneuroim.2010.08.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multiple sclerosis (MS) is the most common neurological disease of the central nervous system affecting young adults. While the etiology of the disease is still unknown, epidemiological and genetics studies have shown a significant inherited component involved in MS pathogenesis. Single nucleotide polymorphisms (SNPs) associated with MS have been recently evaluated by two main groups of high-throughput genotyping analyses: candidate gene approaches and genome-wide association studies (GWAS). Although both types of studies have identified polymorphisms in the human leukocyte antigen (HLA) region as the strongest susceptibility loci for MS, recent investigations have identified a broad spectrum of non-HLA genes prominently associated with MS. This review will focus on recent findings in non-HLA genes as well as their SNPs which have shown high linkage to MS as a genetic-based disorder. Understanding of non-HLA polymorphisms will help elucidate the signalling aberrations involved in MS development and may help to identify novel, personalized approaches to therapy. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：5 / 15

页数：11

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