DABCO-catalyzed one-pot three component synthesis of dihydropyrano[3,2-c]chromene substituted quinazolines and their evaluation towards anticancer activity

被引：25

作者：

Vodnala, Sumathi ^{[1
]}

Bhavani, A. K. D. ^{[1
]}

Kamutam, Ramakrishna ^{[1
]}

Naidu, V. G. M. ^{[2
]}

Promila ^{[3
]}

Prabhakar, Ch. ^{[3
]}

机构：

[1] Osmania Univ, Univ Coll Sci, Dept Chem, Hyderabad 500004, Andhra Pradesh, India

[2] Natl Inst Pharmaceut Educ & Res NIPER, Hyderabad, Andhra Pradesh, India

[3] Natl Inst Technol, Dept Chem, Kurukshetra 36119, Haryana, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 16期

关键词：

Multicomponent reaction; Knoevenagel-Michael reaction; Quinazoline; 4-Hydroxycoumarin; DABCO; Anti-cancer; DISCOVERY; DERIVATIVES; ANTAGONISTS; INHIBITORS; ALKALOIDS; CHEMISTRY; RECEPTOR; AGENTS;

D O I：

10.1016/j.bmcl.2016.07.003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A facile DABCO promoted one-pot three component synthesis of a new series of C-C linked bis-hetero-cycle containing dihydropyrano[c]chromene as highly fused oxa-heteryl group at C-2 position of quinazoline was developed. Quinazoline-2-carbaldehyde, substituted 4-hydroxycoumarin and ethyl cyanoacetate were used as key components in the Knoevenagel-Michael addition reaction to get the titled compounds. These compounds were screened for anti-cancer activity against the breast cancer cell lines of MDA-MB 231, and MDA-MB 453. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：3973 / 3977

页数：5

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