Envisioning an enzymatic Diels-Alder reaction by in situ acid-base catalyzed diene generation

被引：12

作者：

Linder, Mats ^{[1
]}

Johansson, Adam Johannes ^{[1
]}

Manta, Bianca ^{[1
]}

Olsson, Philip ^{[1
]}

Brinck, Tore ^{[1
]}

机构：

[1] KTH Royal Inst Technol, S-10044 Stockholm, Sweden

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 45期

关键词：

DELTA(5)-3-KETOSTEROID ISOMERASE; 3-OXO-DELTA-5-STEROID ISOMERASE; NONCOVALENT INTERACTIONS; THERMOCHEMICAL KINETICS; DENSITY FUNCTIONALS; ANTIBODY CATALYSIS; DESIGN; CYCLOADDITIONS; REARRANGEMENTS; ENERGETICS;

D O I：

10.1039/c2cc31502e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We present and evaluate a new and potentially efficient route for enzyme-mediated Diels-Alder reactions, utilizing general acid-base catalysis. The viability of employing the active site of ketosteroid isomerase is demonstrated.

引用

收藏

页码：5665 / 5667

页数：3

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