Oxidative stress markers in hemodialysis and peritoneal dialysis patients, including coenzyme Q10 and ischemia-modified albumin

Objectives: Oxidative stress results from an imbalance between the production of free radicals and antioxidant activity. There is wide agreement that patients undergoing regular dialysis treatment experience increased oxidative stress. The aim of this study was to investigate serum total antioxidant status (TAS), total oxidant status (TOS), ischemia-modified albumin (IMA), and coenzyme Q(10)(CoQ(10)) levels in hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients, compared with controls. Methods: This study was performed on 41 (21 men, 20 women) CAPD patients, 38 (20 men, 18 women) HD patients, and 43 (23 men, 20 women) healthy control subjects. CoQ(10) levels were standardized using blood lipids. Results: Serum TAS levels and CoQ(10)/total cholesterol values of the HD and CAPD patients were significantly lower, whereas serum IMA and TOS levels were significantly higher, than those of controls. Furthermore, CoQ(10)/LDL, CoQ(10)/triglycerides, and CoQ(10)/total cholesterol + triglycerides values of the CAPD patients were significantly lower than those of controls. No differences were found between serum IMA, TAS, TOS, CoQ(10) levels, and adjusted CoQ(10) values of the CAPD and HD patients. Conclusions: Our results suggest that oxidative stress is increased in HD and CAPD patients compared with controls, as proven by decreased TAS and adjusted CoQ(10) levels and increased TOS and IMA levels. Therefore, an antioxidant supplementation to these patients may be suggested.