Asymmetric Dimethylarginine (ADMA) in Pediatric Renal Diseases: From Pathophysiological Phenomenon to Clinical Biomarker and Beyond

被引：11

作者：

Hsu, Chien-Ning ^{[1
,2
]}

Tain, You-Lin ^{[3
,4
]}

机构：

[1] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan

[2] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan

[3] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Coll Med, Kaohsiung 833, Taiwan

[4] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Coll Med, Kaohsiung 833, Taiwan

来源：

CHILDREN-BASEL | 2021年 / 8卷 / 10期

关键词：

asymmetric dimethylarginine; biomarker; dimethylamine; kidney disease; nitric oxide; children; dimethylarginine dimethylaminohydrolase; protein arginine methyl transferase; pediatric nephrology; BLOOD-PRESSURE ABNORMALITIES; CHRONIC KIDNEY-DISEASE; NITRIC-OXIDE SYNTHESIS; SYMMETRIC DIMETHYLARGININE; HUMAN PLASMA; L-ARGININE; TRANSCRIPTOME ANALYSIS; PREVENTS HYPERTENSION; DIMETHYLAMINOHYDROLASE; CHILDREN;

D O I：

10.3390/children8100837

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide (NO) synthase inhibitor, inhibits NO synthesis and contributes to the pathogenesis of many human diseases. In adults, ADMA has been identified as a biomarker for chronic kidney disease (CKD) progression and cardiovascular risk. However, little attention is given to translating the adult experience into the pediatric clinical setting. In the current review, we summarize circulating and urinary ADMA reported thus far in clinical studies relating to kidney disease in children and adolescents, as well as systematize the knowledge on pathophysiological role of ADMA in the kidneys. The aim of this review is also to show the various analytical methods for measuring ADMA and the issues tht need to be addressed before transforming to clinical practice in pediatric medicine. The last task is to suggest that ADMA may not only be suitable as a diagnostic or prognostic biomarker, but also a promising therapeutic strategy to treat pediatric kidney disease in the future.

引用

页数：13

共 86 条

[1]

Anderstam B, 1997, J AM SOC NEPHROL, V8, P1437

[2] Anti-hypertensive effects of shichimotsukokato in 5/6 nephrectomized Wistar rats mediated by the DDAH-ADMA-NO pathway [J].

Bai, Fan ;

Makino, Toshiaki ;

Ono, Takahiko ;

Mizukami, Hajime .

JOURNAL OF NATURAL MEDICINES, 2012, 66 (04) :583-590

[3]

Beltowski J, 2006, PHARMACOL REP, V58, P159

[4] Plasma biomarker discovery for early chronic kidney disease diagnosis based on chemometric approaches using LC-QTOF targeted metabolomics data [J].

Benito, S. ;

Sanchez-Ortega, A. ;

Unceta, N. ;

Jansen, J. J. ;

Postma, G. ;

Andrade, F. ;

Aldamiz-Echevarria, L. ;

Buydens, L. M. C. ;

Goicolea, M. A. ;

Barrio, R. J. .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2018, 149 :46-56

[5] The L-arginine paradox:: Importance of the L-arginine/asymmetrical dimethylarginine ratio [J].

Bode-Boeger, Stefanie M. ;

Scalera, Fortunato ;

Ignarro, Louis J. .

PHARMACOLOGY & THERAPEUTICS, 2007, 114 (03) :295-306

[6] Determination of Asymmetric and Symmetric Dimethylarginine in Serum from Patients with Chronic Kidney Disease: UPLC-MS/MS versus ELISA [J].

Boelaert, Jente ;

Schepers, Eva ;

Glorieux, Griet ;

Eloot, Sunny ;

Vanholder, Raymond ;

Lynen, Frederic .

TOXINS, 2016, 8 (05)

[7] Nitric oxide may prevent hypertension early in diabetes by counteracting renal actions of superoxide [J].

Brands, MW ;

Bell, TD ;

Gibson, B .

HYPERTENSION, 2004, 43 (01) :57-63

[8] Methylated arginine derivatives in children and adolescents with chronic kidney disease [J].

Brooks, Ellen R. ;

Langman, Craig B. ;

Wang, Sihe ;

Price, Heather E. ;

Hodges, Abigail L. ;

Darling, Lara ;

Yang, Amy Z. ;

Smith, Frederick A. .

PEDIATRIC NEPHROLOGY, 2009, 24 (01) :129-134

[9]

Chen D, 2017, ASIAN J ANDROL, V19, P291, DOI [10.4103/1008-682X.178486, 10.4103/1008-682x.178486]

[10] Homocysteine and Arginine-to-Asymmetric Dimethylarginine Ratio Associated With Blood Pressure Abnormalities in Children With Early Chronic Kidney Disease [J].

Chien, Shao-Ju ;

Lin, I-Chun ;

Hsu, Chien-Ning ;

Lo, Mao-Hung ;

Tain, You-Lin .

CIRCULATION JOURNAL, 2015, 79 (09) :2031-2037

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