Synthesis of Aryl Aldimines and Their Activity against Fungi of Clinical Interest

被引：26
作者：
da Silva, Cleiton M. [1 ]
da Silva, Danielle L. [1 ,2 ]
Martins, Cleide V. B. [2 ,3 ]
de Resende, Maria A. [2 ]
Dias, Esther S. [1 ]
Magalhaes, Thais F. F. [2 ]
Rodrigues, Leticia P. [1 ]
Sabino, Adao A. [1 ]
Alves, Rosemeire B. [1 ]
de Fatima, Angelo [1 ,2 ]
机构：
[1] Univ Fed Minas Gerais, GEQOB, Dept Quim, ICEx, BR-31270901 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Dept Microbiol, ICB, BR-31270901 Belo Horizonte, MG, Brazil
[3] UNIOESTE, Ctr Engn & Ciencias Exatas, BR-85903000 Umuarama, PR, Brazil
来源：
CHEMICAL BIOLOGY & DRUG DESIGN | 2011年 / 78卷 / 05期
关键词：
Antifungal activity; aryl aldimines; Aspergillus spp; biofilm; Candida spp; Cryptococcus neoformans; SCHIFF-BASES; ANTIFUNGAL THERAPY; INFECTIONS; INHIBITORS; AGENTS; DERIVATIVES; TRANSPLANT; MORTALITY; FUNGEMIA; TARGETS;
D O I：
10.1111/j.1747-0285.2011.01185.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aldimines are aldehyde-derived compounds that contain a C=N group. Besides its broad industrial applications, this class of non-naturally occurring compounds are found to possess antibacterial, antifungal, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties. Based on this, six aryl aldimines were synthesized from the condensation of aromatic amines with benzaldehydes. The antifungal activities of synthesized compounds were evaluated against nineteen fungal strains that included Candida and Aspergillus species, Cryptococcus neoformans. The aryl aldimines 2-(benzylideneamino)phenol (3) and 4-(benzylideneamino)phenol (8) were the most active compounds against the fungi studied. Compounds 3 and 8 efficiently inhibited the metabolism of C. neoformans mature biofilm.
引用
收藏
页码：810 / 815
页数：6
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