Growth hormone receptor promotes breast cancer progression via the BRAF/MEK/ERK signaling pathway

被引：20

作者：

Zhu Xiaojue ^{[1
]}

Li Yonghao ^{[1
]}

Xu Guoxin ^{[1
]}

Fu ChangQing ^{[2
]}

机构：

[1] Suzhou Univ, Zhangjiagang Peoples Hosp 1, Clin Lab, 68 Jiyang West Rd, Suzhou 215600, Jiangsu, Peoples R China

[2] Zhangjiagang Fifth Peoples Hosp, 120 Lefeng Rd, Suzhou 215621, Jiangsu, Peoples R China

来源：

FEBS OPEN BIO | 2020年 / 10卷 / 06期

关键词：

apoptosis; BRAF; MEK; ERK signaling pathway; breast cancer; cell cycle; GHR; EXPRESSION; APOPTOSIS; PROGNOSIS; MECHANISM; GH;

D O I：

10.1002/2211-5463.12816

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Growth hormone receptor (GHR), a member of the class I cytokine receptor family, plays key roles in cancer progression. Recently, GHR has been reported to be associated with breast cancer development, but the molecular mechanism of GHR in this malignancy is not fully understood. To investigate this issue, we stably inhibited GHR in breast cancer cell lines, which were observed to reduce cell proliferation, tumor growth and induction of apoptosis, and arrest the cell-cycle arrest at the G1-S phase transition. In addition, GHR silencing suppressed the protein levels of B-Raf proto-oncogene, serine/threonine kinase (BRAF), Mitogen-activated protein kinase kinase (MEK) and Extracellular regulated protein kinases (ERK). These findings suggest that GHR may mediate breast cell progression and apoptosis through control of the cell cycle via the BRAF/MEK/ERK signaling pathway.

引用

页码：1013 / 1020

页数：8

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